Principles of Molecular Medicine

  • J. Larry Jameson

Table of contents

  1. Front Matter
    Pages i-xix
  2. Introduction to Molecular Medicine

    1. Front Matter
      Pages 1-1
    2. Sarah H. Elsea, Pragna I. Patel
      Pages 3-7
    3. Marcus Grompe, Wade Johnson, J. Larry Jameson
      Pages 9-24
    4. Wade Johnson, J. Larry Jameson
      Pages 25-41
    5. Peter Kopp, J. Larry Jameson
      Pages 43-58
    6. J. Larry Jameson
      Pages 59-63
    7. Lynda Q. Nguyen, J. Larry Jameson
      Pages 65-72
    8. J. Larry Jameson
      Pages 73-82
    9. C. Sue Richards, Patricia A. Ward
      Pages 83-88
    10. Beth A. Fine
      Pages 89-95
    11. T. Rajendra Kumar, Martin M. Matzuk
      Pages 97-110
  3. Cardiology

    1. Front Matter
      Pages 111-111
    2. Anthony Rosenzweig
      Pages 113-115
    3. Alvin J. Chin
      Pages 117-125
    4. Christine E. Seidman, Calum MacRae, J. G. Seidman
      Pages 127-132
    5. Robert E. Gerszten, Anthony Rosenzweig
      Pages 133-140
    6. Santiago Lamas, Thomas Michel
      Pages 141-144
    7. George Koike, Howard J. Jacob
      Pages 145-155
    8. Barry London
      Pages 157-160
    9. Giuseppe Vassalli, David A. Dichek
      Pages 161-168
  4. Hematology

    1. Front Matter
      Pages 169-169
    2. Andrew Haynes, Nigel Russell
      Pages 171-178
    3. Swee Lay Thein, Jacques Rochette
      Pages 179-190
    4. Jean Delaunay
      Pages 191-195
    5. Lucio Luzzatto, Rosario Notaro
      Pages 197-207
    6. Martina Daly, Anne Goodeve, Peter Winship, Ian Peake
      Pages 209-217
    7. Robin J. Olds, David A. Lane, Swee Lay Thein
      Pages 219-226
    8. Bruno Rotoli, Khedoudja Nafa
      Pages 227-232
    9. Jeffrey E. Rubnitz, Ching-Hon Pui
      Pages 233-239
    10. Finbarr E. Cotter
      Pages 241-248
  5. Immunology

    1. Front Matter
      Pages 249-249
    2. Ralph C. Williams Jr.
      Pages 251-258
    3. William L. Lowe Jr., Barbara A. da Silva
      Pages 267-271
    4. Robert W. Karr
      Pages 273-281
    5. Richard Hong
      Pages 283-291
    6. John W. Sleasman, Maureen M. Goodenow
      Pages 293-297
    7. N. Lawrence Edwards
      Pages 299-307
    8. Susan M. MacDonald
      Pages 309-316
  6. Pulmonology

    1. Front Matter
      Pages 317-317
    2. Michael J. Holtzman, Dwight C. Look, Michael F. Iademarco, Douglas C. Dean, Deepak Sampath, Mario Castro
      Pages 319-327
    3. Daniel B. Rosenbluth, Steven L. Brody
      Pages 329-338
    4. Steven D. Shapiro, Robert M. Senior
      Pages 339-347
    5. Jeffrey A. Whitsett, Timothy E. Weaver
      Pages 349-355
    6. Steven Jay Weintraub
      Pages 357-361
  7. Gastroenterology

    1. Front Matter
      Pages 363-363
    2. Piet C. de Groen, Nicholas F. LaRusso
      Pages 365-374
    3. Juan Ruiz, George Y. Wu
      Pages 375-386
    4. Sanjeev Gupta, Michael Ott
      Pages 387-400

About this book


Principles of Molecular Medicine is the first major textbook to integrate the basic principles of internal medicine with the rapidly growing body of revolutionary findings from cell and molecular biology, including the human genome project. In its pages, J. Larry Jameson and his authoritative contributors, many of them world-renowned clinicians and researchers, expand the envelope of clinical understanding to encompass a wide array of specialties-including neurology, cardiology, hematology, nephrology, genetics, endocrinology, oncology, dermatology, and psychiatry-revealing the underlying molecular mechanisms of disease, as well as novel routes to the unprecedented treatments now emerging from these new molecular approaches.

Practicing physicians will find informative updates in both their own specialties and in disciplines they may not have been able to follow closely. Within the framework of clinical internal medicine, they will gain critical knowledge of the many powerful molecular biology-based developments now so rapidly enhancing our understanding of the pathophysiology of disease, improving the feasibility and accuracy of diagnostic testing, and opening novel therapeutic avenues, including gene therapy. Readers will also gain a fuller understanding of the role played by genetic defects in a host of diseases, among them peripheral neuropathies, Alzheimer's disease, arrhythmias, leukemias and lymphomas, cystic fibrosis, hepatitis, HIV, autoimmune disorders, polycystic kidney disease, schizophrenia, affective disorders, alcoholism, Huntington's disease, and many more.

Principles of Molecular Medicine offers a brilliant and original synthesis of today's rapidly advancing insights-fostered by genetics and molecular biology-into the nature and treatment of disease, codifying the major paradigm shift now underway in the teaching and practice of medicine. Certain to become a vital complement to traditional medical textbooks, Principles of Molecular Medicine provides practicing physicians, residents, medical students, and researchers alike with an authoritative and practical account of today's internal medicine, as well as insights into the nature and direction of future developments.


AIDS DNA Termination cell gene expression gene therapy genes genetics genome hematology immunity leukemia molecular mechanisms molecular medicine transcription

Editors and affiliations

  • J. Larry Jameson
    • 1
  1. 1.Division of Endocrinology, Metabolism, and Molecular MedicineNorthwestern University Medical SchoolChicagoUSA

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