Antifolate Drugs in Cancer Therapy

  • Ann L. Jackman

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-x
  2. Robert C. Jackson
    Pages 1-12
  3. G. J. Peters, C. H. Köhne
    Pages 101-145
  4. Leslie R. Hughes, Trevor C. Stephens, F. Thomas Boyle, Ann L. Jackman
    Pages 147-165
  5. Philip Beale, Stephen Clarke
    Pages 167-181
  6. Gary K. Smith, Joseph W. Bigley, Inderjit K. Dev, David S. Duch, Robert Ferone, William Pendergast
    Pages 203-227
  7. F. Thomas Boyle, Trevor C. Stephens, S. D. Averbuch, Ann L. Jackman
    Pages 243-260
  8. Theodore J. Boritzki, Cathy Zhang, Charlotte A. Bartlett, Robert C. Jackson
    Pages 281-292
  9. Julio Barredo, Marlene A. Bunni, Raghunathan Kamasamudram, David G. Priest
    Pages 323-337
  10. Stephen P. Ackland, Rosemary Kimbell
    Pages 365-382
  11. Edward Chu, Jingfang Ju, John C. Schmitz
    Pages 397-408

About this book

Introduction

In Antifolate Drugs in Cancer Therapy, Ann Jackman and a panel of highly regarded researchers comprehensively review the current status of novel antifolates, an important class of anticancer drugs. The distinguished contributors discuss the preclinical and clinical pharmacology of methotrexate, other dihydrofolate reductase inhibitors,
5-fluorouracil, and the new generation of antifolates-the thymidylate synthase and glycinamide ribonucleotide formyltransferase inhibitors. In addition, they review in depth the modulation of antifolate drugs, folate and antifolate transport mechanisms, polyglutamation, resistance, and drug combinations, as well as pharmacogenomics, pharmacodynamics, regulation of gene expression, and mechanisms of cell death.

The wide and progressive scope of Antifolate Drugs in Cancer Therapy provides entré to exciting new avenues for future research, and constitutes a new standard reference for all basic scientists and clinicians engaged in cancer therapeutics.

Keywords

biochemistry cancer cancer therapy cell cell death chemotherapy drug drugs future genomics immunotherapy pharmacodynamics pharmacology research resistance

Editors and affiliations

  • Ann L. Jackman
    • 1
  1. 1.The Cancer Research Campaign Centre for Cancer TherapeuticsThe Institute of Cancer ResearchSutton, SurreyUK

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-59259-725-3
  • Copyright Information Humana Press 1999
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4757-4521-4
  • Online ISBN 978-1-59259-725-3
  • About this book