Apoptosis and Cancer Chemotherapy

  • John A. Hickman
  • Caroline Dive

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Scott W. Lowe
    Pages 21-36
  3. Wafik S. El-Deiry
    Pages 37-52
  4. Sandra J. Campbell, Mary O’Neill, Peter A. Hall
    Pages 53-68
  5. Zhi-Min Yuan, Surender Kharbanda, Ralph Weichselbaum, Donald Kufe
    Pages 87-98
  6. John C. Reed
    Pages 99-116
  7. Yi-Te Hsu, Richard Youle
    Pages 117-128
  8. Jean-Claude Martinou, Bruno Antonsson
    Pages 129-141
  9. Douglas R. Green, Helen M. Beere
    Pages 157-174
  10. Klaus-Michael Debatin
    Pages 175-187
  11. Renato Baserga, Mariana Resnicoff
    Pages 189-203
  12. Sian T. Taylor, Caroline Dive
    Pages 205-221
  13. Constantinos Koumenis, Nicholas Denko, Amato J. Giaccia
    Pages 223-240
  14. Timothy J. McDonnell, Elizabeth M. Bruckheimer, Bjorn T. Gjertsen, Tsuyoshi Honda, Nora M. Navone
    Pages 241-255
  15. Jonathan L. Tilly, Alan L. Johnson
    Pages 257-273
  16. Nancy E. Davidson, Hillary A. Hahm, Deborah K. Armstrong
    Pages 291-303
  17. Garrett M. Brodeur, Valerie P. Castle
    Pages 305-318
  18. Christine M. Chresta
    Pages 319-329
  19. Joseph R. Bertino
    Pages 331-332
  20. Back Matter
    Pages 333-342

About this book


The past few years have witnessed an astonishing international effort that established the role of some 20 new molecules in apoptosis and added activation or suppression of apoptosis to the accepted biological functions of a great many others already familiar in cancer biology. Some of these molecules are receptors, transducing cytokine-mediated signals; others appear to intensify or diminish the risk that a compro­ mised cell will fire its apoptosis effector mechanism. All are of interest as potential targets for tumor therapy, and some may prove to be control points influenced in the pathogenesis of cancer and other diseases as diverse as viral infection, neurodegenerative disorders, and stroke. Sometimes, in the midst of these developments, a kind of euphoria ap­ pears to have gripped the research community, with the expectation that apoptosis will afford explanations to many unsolved questions in cellu­ lar regulation. This book, in a series of thoughtful and provocative ar­ ticles--some from established leaders in the field, and others from younger scientists--seeks to redress the balance.


Activation DNA apoptosis cancer cell cell death chemotherapy cytokine influence lymphoma oncogenes regulation research resistance tumor

Editors and affiliations

  • John A. Hickman
    • 1
  • Caroline Dive
    • 1
  1. 1.Cancer Research Campaign, Molecular and Cellular Pharmacology Group, School of Biological SciencesUniversity of ManchesterUK

Bibliographic information