Insulin Resistance

The Metabolic Syndrome X

  • Gerald M. Reaven
  • Ami Laws

Part of the Contemporary Endocrinology book series (COE, volume 12)

Table of contents

  1. Front Matter
    Pages i-x
  2. Genetic and Environmental Factors Affecting Insulin Action

    1. Front Matter
      Pages 1-1
    2. Michael P. Stern, Braxton D. Mitchell
      Pages 3-18
    3. Jean-Pierre Després, André Marette
      Pages 51-81
    4. Flemming Dela, Kári Mikines, Henrik Galbo
      Pages 97-120
  3. Pathophysiology of Insulin Resistance

    1. Front Matter
      Pages 137-137
    2. Jack F. Youngren, Ira D. Goldfine, Vincenzo Trischitta, Betty A. Maddux
      Pages 139-158
    3. Gianluca Perseghin, Kitt Falk Petersen, Gerald I. Shulman
      Pages 159-177
    4. Jerry Radziuk, Susan Pye
      Pages 197-231
    5. Alain D. Baron, Michael J. Quon
      Pages 247-263
  4. Clinical Syndromes Associated with Insulin Resistance

    1. Front Matter
      Pages 265-265
    2. Ele Ferrannini
      Pages 281-308
    3. Jeannie Yip, Roberto Trevisan
      Pages 309-316
    4. Irène Juhan-Vague, Marie-Christine Alessi, Pierre E. Morange
      Pages 317-332
    5. Aaron R. Folsom
      Pages 333-346
  5. Back Matter
    Pages 367-374

About this book


In Insulin Resistance: The Metabolic Syndrome X, outstanding investigators thoughtfully summarize our current understanding of how insulin resistance and its compensating hyperinsulinemia (Syndrome X) play a major role in the pathogenesis and clinical course of high blood pressure and cardiovascular disease-the so-called diseases of Western civilization-as well as polycystic ovary disease. Under the aegis of Gerald Reaven, the discoverer of Syndrome X, the distinguished authorities writing here detail for the first time the pathophysiological consequences and the clinical syndromes, excluding Type 2 diabetes, related to insulin resistance. They also examine the genetic and lifestyle factors that contribute to the wide differences in insulin action that exist in the population at large. Each author has been encouraged to present a point of view that reflects their unique insights.
The first authoritative book on the subject, Insulin Resistance: The Metabolic Syndrome X illuminates the special importance of insulin resistance as a major cause of hypertension, heart disease, and polycystic ovary syndrome. Its thoughtful and detailed approach will make it an essential reference for basic and clinical researchers seeking to understand these critical phenomena.


Diabetes endothelium insulin insulin resistance pathophysiology physiology skeletal muscle tissue

Editors and affiliations

  • Gerald M. Reaven
    • 1
    • 2
  • Ami Laws
    • 3
  1. 1.Shaman Pharmaceuticals, Inc.South San FranciscoUSA
  2. 2.Stanford University School of MedicineStanfordUSA
  3. 3.Stanford University School of MedicineStanfordUSA

Bibliographic information