The IGF System

Molecular Biology, Physiology, and Clinical Applications

  • Ron G. Rosenfeld
  • Charles T. RobertsJr.

Part of the Contemporary Endocrinology book series (COE, volume 17)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Historical Perspective

    1. William H. Daughaday, William D. Salmon Jr
      Pages 1-15
  3. Molecular Biology of the IGF System

    1. Front Matter
      Pages 17-17
    2. Peter Rotwein
      Pages 19-35
    3. P. Elly Holthuizen, Paul H. Steenbergh, John S. Sussenbach
      Pages 37-61
    4. Guck T. Ooi, Yves R. Boisclair
      Pages 111-139
  4. Biological Actions of the IGFs

    1. Front Matter
      Pages 141-141
    2. Vicky A. Blakesley, Andrew A. Butler, Anatolii P. Koval, Yumiko Okubo, Derek LeRoith
      Pages 143-163
    3. S. Peter Nissley
      Pages 165-197
    4. Kenneth Siddle, Maria A. Soos
      Pages 199-225
    5. Janet L. Martin, Robert C. Baxter
      Pages 227-255
    6. Youngman Oh, Ron G. Rosenfeld
      Pages 257-272
    7. David R. Clemmons
      Pages 273-279
    8. Michel Binoux, Claude Lalou, Sarah Mohseni-Zadeh
      Pages 281-313
    9. Vivian Hwa, Youngman Oh, Christine P. Burren, Won Kyu Choi, Donna L. Graham, Angela Ingermann et al.
      Pages 315-327
    10. Renato Baserga, Marco Prisco, Atsushi Hongo
      Pages 329-353
  5. IGF Physiology

    1. Front Matter
      Pages 377-377

About this book


It has been over 40 years since the original report by Salmon and Daughaday demon­ strating that the ability of GH to stimulate sulfation of cartilage was mediated by a "sulfation factor. " In the ensuing decades, it has become apparent that this "sulfation factor activity" encompasses a complex system ofligands (IGFs), receptors, and carrier proteins that are, in tum, responsible for a wide array of cellular actions. The IGF system has been demonstrated to be critically involved in both intrauterine and postnatal growth, and to have important implications in cancer biology as well, owing to the ability of the IGFs to function in endocrine, paracrine, and autocrine modes and given the wide distri­ bution of IGFs in virtually every organ system. The contributions to The /GF System reflect the wide span of interest in the IGF system and its implications for normal and abnormal growth and metabolism. The chapters have been divided into four broad sections: I. Molecular biology of the IGF system; II. Bio­ logical actions of the IGFs; III. IGF physiology; and IV. Clinical aspects of the IGFs. We have made every effort to highlight the major contemporary themes in IGF biology, but as is inevitable in such a fast-moving field, perspectives will continue to change as new information is accumulated.


Altern Diabetes G proteins Translation bone development gene expression genes growth factor insulin-like molecular biology physiology signaling system skeletal muscle

Editors and affiliations

  • Ron G. Rosenfeld
    • 1
  • Charles T. RobertsJr.
    • 2
  1. 1.Department of Pediatrics, School of MedicineOregon Health Sciences UniversityPortlandUSA
  2. 2.Oregon Health Sciences UniversityPortlandUSA

Bibliographic information

  • DOI
  • Copyright Information Humana Press 1999
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-61737-138-7
  • Online ISBN 978-1-59259-712-3
  • About this book