Lupus

Molecular and Cellular Pathogenesis

  • Gary M. Kammer
  • George C. Tsokos

Part of the Contemporary Immunology book series (CONTIM)

Table of contents

  1. Front Matter
    Pages i-xx
  2. Evelyn V. Hess
    Pages 1-12
  3. Bruce N. Cronstein, Allison Reiss, Sandeep Malhotra
    Pages 13-20
  4. H. Michael Belmont, Ashok R. Amin, Steven B. Abramson
    Pages 21-42
  5. Rebecca S. Tuetken, Ae-Kyung Yi, Arthur M. Krieg
    Pages 79-100
  6. Pércio S. Gulko, Robert J. Winchester
    Pages 101-123
  7. Chandra Mohan, Laurence Morel, Edward K. Wakeland
    Pages 124-139
  8. Andrei Shustov, Violetta Rus, Phuong Nguyen, Charles S. Via
    Pages 140-151
  9. Stanford L. Peng, Joe Craft
    Pages 152-166
  10. Stamatis-Nick C. Liossis, George C. Tsokos
    Pages 167-180
  11. Mark J. Mamula
    Pages 202-219
  12. Jeannine M. Scott, Bruce C. Richardson
    Pages 278-298
  13. David A. Horwitz, J. Dixon Gray, Katzuo Ohtsuka, Bricia Toro, Mary M. Stimmler, Lillie Hsu
    Pages 312-320

About this book

Introduction

Leading basic and clinical investigators from around the world summarize the most recent research on the molecular and cellular origins of lupus. Their cutting-edge articles review the mechanisms underlying abnormal immunity and introduce the powerful new concept that a disorder of multiple genes underlies the abnormal immune response, leading directly to the development of lupus. This pathophysiology is shown to involve a wide variety of cell types, including T cells, B cells, natural killer cells, macrophages/monocytes, and endothelial cells. Over time, the resulting long-term inflammation causes irreversible cell destruction and, ultimately, organ failure. Lupus: Molecular and Cellular Pathogenesis is a masterful new synthesis of all the new knowledge emerging today about lupus. Its new perspectives will sharpen the focus of research and ultimately lead to better and more effective treatment.

Keywords

Antigen apoptosis autoimmunity bacteria cytokine genetics inflammation lymphocytes macrophages pathogenesis pathophysiology physiology therapy thrombosis

Editors and affiliations

  • Gary M. Kammer
    • 1
  • George C. Tsokos
    • 2
    • 3
  1. 1.Section on Rheumatology, Department of Internal MedicineThe Wake Forest University School of MedicineWinston-SalemUSA
  2. 2.Division of Rheumatology and ImmunologyUniformed Services University of Health SciencesBethesdaUSA
  3. 3.Department of Clinical PhysiologyWalter Reed Army Institute of ResearchUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-59259-703-1
  • Copyright Information Humana Press 1999
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4757-5686-9
  • Online ISBN 978-1-59259-703-1
  • About this book