Central Nervous System Diseases

Innovative Animal Models from Lab to Clinic

  • Dwaine F. Emerich
  • Reginald L. DeanIII
  • Paul R. Sanberg

Part of the Contemporary Neuroscience book series (CNEURO)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Aging and Alzheimer’s Disease

    1. Front Matter
      Pages 1-1
    2. Raymond T. Bartus
      Pages 3-45
    3. Mark B. Moss, Ronald J. Killiany, James G. Herndon
      Pages 47-64
    4. James M. Conner, Mark H. Tuszynski
      Pages 65-80
    5. Yasuyuki Nomura, Yasunobu Okuma, Yoshihisa Kitamura
      Pages 113-122
  3. Parkinson’s Disease

    1. Front Matter
      Pages 129-129
    2. Timothy Schallert, Jennifer L. Tillerson
      Pages 131-151
    3. L. E. Annett, R. E. Smyly, J. M. Henderson, R. M. Cummings, A. L. Kendall, S. B. Dunnett
      Pages 171-186
    4. O. Isacson, L. C. Costantini, W. R. Galpern
      Pages 187-207
    5. Simranjit Kaur, Ian Creese
      Pages 209-226
  4. Huntington’s Disease

    1. Front Matter
      Pages 247-247
    2. Peter J. Brasted, Màté D. Döbrössy, Dawn M. Eagle, Falguni Nathwani, Trevor W. Robbins, Stephen B. Dunnett
      Pages 249-273
    3. Emmanuel Brouillet, Philippe Hantraye, M. Flint Beal
      Pages 301-332
    4. Philippe Hantraye, Stéphane Palfi, Vincent Mittoux, Caroline Dautry, Françoise Condé, Emmanuel Brouillet
      Pages 333-353
    5. Gillian P. Bates, Laura Mangiarini, Stephen W. Davies
      Pages 355-367
  5. Traumatic Brain Injury and Stroke

    1. Front Matter
      Pages 369-369
    2. Cesario V. Borlongan, Hitoo Nishino, Yun Wang, Paul R. Sanberg
      Pages 393-406
  6. Innovations Leading to Clinical Therapy

    1. Front Matter
      Pages 429-429
    2. R. Doug Shytle, Archie A. Silver, Mary B. Newman, Paul R. Sanberg
      Pages 431-440
    3. Ben Roitberg, Peter Shin, Joseph Sramek, Jeffrey H. Kordower
      Pages 441-483
    4. Daniel A. Peterson, Jasodhara Ray, Fred H. Gage
      Pages 485-508
  7. Back Matter
    Pages 509-512

About this book


In Central Nervous System Diseases: Innovative Animal Models from Lab to Clinic, prominent experimentalists critically review the animal models widely used in developing powerful new therapies for central nervous system diseases, as well as their advantages and limitations. Coverage includes novel uses of animal models of Alzheimer's, Parkinson's, and Huntington's diseases, and studies of aging. Techniques that rely heavily on behavioral analyses, as well as models developed from infusions of neurotoxins and from advances in molecular biology are thoroughly explicated, as are models developed for more acute neurological conditions, including traumatic brain injury and stroke.
Comprehensive and authoritative, Central Nervous System Diseases: Innovative Animal Models from Lab to Clinic offers neuroscientists, pharmacologists, and interested clinicians a unique survey of the most productive animal models of the leading neurological diseases currently employed to develop today's innovative drug therapies.


Alzheimer Nervous System Parkinson neurons phenotype

Editors and affiliations

  • Dwaine F. Emerich
    • 1
  • Reginald L. DeanIII
    • 2
  • Paul R. Sanberg
    • 3
  1. 1.Alkermes, Inc.CambridgeUSA
  2. 2.Department of NeuroscienceAlkermes, Inc.CambridgeUSA
  3. 3.University of South Florida College of MedicineTampaUSA

Bibliographic information