Principles of Molecular Oncology

  • Miguel H. Bronchud
  • MaryAnn Foote
  • Giuseppe Giaccone
  • Olufunmilayo I. Olopade
  • Paul Workman

Table of contents

  1. Front Matter
    Pages i-xxi
  2. Molecular Markers

    1. Front Matter
      Pages 1-1
    2. Miguel H. Bronchud
      Pages 3-49
    3. Daniel F. Hayes
      Pages 51-72
    4. Antonella Aiello, Elena Tamborini, Milo Frattini, Federica Perrone, Maria Oggionni, Silvana Pilotti et al.
      Pages 73-150
    5. Tatyana A. Grushko, Olufunmilayo I. Olopade
      Pages 151-179
    6. Barbro Linderholm, Thomas Lindahl, John Öhd, Jonas Bergh
      Pages 181-213
    7. Chris Jones, Ming-Qing Du, Sunil R. Lakhani
      Pages 215-232
    8. Alan Horwich, Gill Ross
      Pages 233-246
    9. Rachel A. Craven, Peter J. Selby, Rosamonde E. Banks
      Pages 247-264
  3. Diseased Regulatory Pathways

    1. Front Matter
      Pages 265-265
    2. Daniel Kalderon
      Pages 267-315
    3. Jennifer E. Fox, Hong Liu, V. Craig Jordan
      Pages 317-358
    4. Miguel H. Bronchud, Leonardo Brizuela, Jeno Gyuris, Muzammil M. Mansuri
      Pages 359-410
    5. Jaume Piulats, Francesc Mitjans
      Pages 411-441
    6. Maria Rosa Bani, Raffaella Giavazzi
      Pages 443-461
    7. Linda E. Bröker, José A. Rodriguez, Giuseppe Giaccone
      Pages 463-489
    8. Gabriel Capellá, Miguel Angel Peinado
      Pages 491-504
  4. Future Directions

    1. Front Matter
      Pages 505-505
    2. Angelo A. Cardoso, W. Nicholas Haining, Marina Leite, Sara Maia
      Pages 507-528
    3. Gisela Schwab, Lorin Roskos, C. Geoffrey Davis
      Pages 529-568
    4. Richard Baird, Paul Workman
      Pages 569-606
    5. M. Suzanne Stratton, Steven P. Stratton, Sara O. Dionne, Patricia Thompson, Ian N. Jongewaard, Iman Hakim et al.
      Pages 607-673
    6. Ion Niculescu-Duvaz, Caroline J. Springer
      Pages 675-694
  5. Back Matter
    Pages 695-709

About this book


Drawing on four years of significant scientific advances and clinical developments, the editors of Principles of Molecular Oncology, Second Edition, have thoroughly updated the highly praised first edition and added new chapters to reflect the knowledge emerging from research on genomics, proteomics, chemoprevention strategies, new molecular targets, therapeutic monoclonal antibodies, and innovative cytotoxic and cytostatic small-molecular-weight compounds.
The first edition of this book (Humana Press, 2000) was also the first comprehensive presentation of the concept of cancer as a "disease process" involving key regulatory pathways. The second edition reaffirms this dynamic concept, incorporating more recent evidence, and introducing such new topics of special interest as the combination of molecular diagnostics-expression profiling of genes and proteins-with developmental therapeutics, and the "binary state" concept (active/inactive) that seeks more relevant targets within the global molecular matrix of a given cancer.
Comprehensive and intellectually stimulating, Principles of Molecular Oncology, Second Edition not only clearly elucidates the fundamentals of this dramatically advancing field, but also interprets the vast and often complex molecular data available. It fills a much-neglected gap between "information" and "knowledge," and holds out the hope of new anticancer strategies that will reduce cancer cell proliferation and significantly reduce metastasis.


DNA angiogenesis carcinogenesis diagnostics gene therapy genomics immunotherapy metastasis prevention tumor

Editors and affiliations

  • Miguel H. Bronchud
    • 1
  • MaryAnn Foote
    • 2
  • Giuseppe Giaccone
    • 3
  • Olufunmilayo I. Olopade
    • 4
  • Paul Workman
    • 5
  1. 1.Division of Medical OncologyHospital General de GranollersBarcelonaSpain
  2. 2.Amgen Inc.Thousand OaksUSA
  3. 3.Department of Medical OncologyVU University Medical CenterAmsterdamThe Netherlands
  4. 4.Section of Hematology/Oncology, Department of MedicineUniversity of ChicagoChicagoUSA
  5. 5.Cancer Research UK Centre for Cancer TherapeuticsThe Institute of Cancer Research and Royal Marsden HospitalSutton, SurreyUK

Bibliographic information