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Troubleshooting LC Systems

A Comprehensive Approach to Troubleshooting LC Equipment and Separations

  • John W. Dolan
  • Lloyd R. Snyder

Table of contents

  1. Front Matter
    Pages i-viii
  2. Introduction

    1. John W. Dolan, Lloyd R. Snyder
      Pages 1-9
  3. General Considerations

    1. John W. Dolan, Lloyd R. Snyder
      Pages 11-77
    2. John W. Dolan, Lloyd R. Snyder
      Pages 79-108
    3. John W. Dolan, Lloyd R. Snyder
      Pages 109-118
    4. John W. Dolan, Lloyd R. Snyder
      Pages 119-137
  4. Individual LC Modules

    1. John W. Dolan, Lloyd R. Snyder
      Pages 139-164
    2. John W. Dolan, Lloyd R. Snyder
      Pages 165-200
    3. John W. Dolan, Lloyd R. Snyder
      Pages 201-216
    4. John W. Dolan, Lloyd R. Snyder
      Pages 217-234
    5. John W. Dolan, Lloyd R. Snyder
      Pages 235-290
    6. John W. Dolan, Lloyd R. Snyder
      Pages 291-326
    7. John W. Dolan, Lloyd R. Snyder
      Pages 327-366
    8. John W. Dolan, Lloyd R. Snyder
      Pages 367-383
  5. Troubleshooting the Separation plus Other Problems

    1. John W. Dolan, Lloyd R. Snyder
      Pages 385-423
    2. John W. Dolan, Lloyd R. Snyder
      Pages 425-454
    3. John W. Dolan, Lloyd R. Snyder
      Pages 455-479
    4. John W. Dolan, Lloyd R. Snyder
      Pages 481-500
  6. Back Matter
    Pages 501-515

About this book

Introduction

Over the last 15 years, high-performance liquid chromatogra­ phy (LC) has made the transition from an instrument used only by experts in research labs to a tool used for routine applications by relatively unskilled workers. With this transition have come in instrumentation and column technology. In major advances the past, the operator had to be a jack-of-all-trades, with a screw­ driver, soldering iron, and various wrenches as constant compan­ ions in the LC lab. Today, many instruments contain micropro­ cessors as powerful as those of mainframe computers of earlier days. With this technology has come a variety of self-diagnostic tools that allow the LC system to locate many of its own prob­ lems. Traditionally, well-honed LC troubleshooting skills have been a result of years of work at the bench. Today the LC system itself often can do a better job of troubleshooting than the operator can. Yet many of the problems of the past are still the major problems of today: air bubbles, check valves, detector lamps, and, of course, problems with the separation. An added pressure on the operator of today's LC system is that of productivity-the lab often cannot afford unnecessary downtime. This means that the operator has to be a troubleshooting expert, or has to have that expertise at his or her fingertips. The present book was written to provide this expertise in an easy-to-use format for users at all levels of experience.

Keywords

Chromat chromatography growth maintenance reactions system temperature

Authors and affiliations

  • John W. Dolan
    • 1
  • Lloyd R. Snyder
    • 1
  1. 1.LC Resources Inc.Walnut CreekUSA

Bibliographic information