Cerebral Ischemia

Molecular and Cellular Pathophysiology

  • Wolfgang Walz

Part of the Contemporary Neuroscience book series (CNEURO)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Overview

    1. Front Matter
      Pages 1-1
    2. Costantino Iadecola
      Pages 3-32
  3. Factors in the Brain Microenvironment

    1. Front Matter
      Pages 33-33
    2. Harold K. Kimelberg
      Pages 45-67
    3. Paul Morley, Joseph S. Tauskela, Antoine M. Hakim
      Pages 69-104
    4. Pak H. Chan
      Pages 105-123
    5. Annadora J. Bruce-Keller, Mark P. Mattson
      Pages 125-142
  4. Cellular Changes

    1. Front Matter
      Pages 143-143
    2. Thaddeus S. Nowak Jr., Marika Kiessling
      Pages 145-215
    3. Koji Abe
      Pages 217-232
    4. Ronald Jabs, Lane K. Bekar, Wolfgang Walz
      Pages 233-249
    5. Yoichi Kondo
      Pages 251-269
  5. Back Matter
    Pages 271-278

About this book


In Cerebral Ischemia: Molecular and Cellular Pathphysiology, Wolfgang Walz and a panel of leading authorities illuminate those cellular and molecular mechanisms brought into play during a stroke that lead to neuronal dysfunction. Such damaging factors as spreading depression waves and postischemic depolarization, cell swelling, calcium overload, and oxygen radicals leading to necrosis and apoptosis are described in detail. Also examined are the body's repair mechanisms involving altered gene expression that lead to trophic factor production and heat shock protein synthesis, as well as to astrogliosis and microgliosis. All factors are presented in relation to their therapeutic value and the possible treatment approaches that evolve from their interactions.
Cerebral Ischemia: Molecular and Cellular Pathophysiology offers clinicians, interested practitioners, and experimentalists alike a systematic evaluation of all the major biological systems that contribute to brain dysfunction after a vascular accident. Its unique focus on mechanisms and gene expression also provides fresh and powerful insights into the many novel therapeutic strategies and agents for stroke management emerging today.


brain brain injury cell cerebral ischemia depression pathophysiology physiology

Editors and affiliations

  • Wolfgang Walz
    • 1
  1. 1.Department of Physiology, College of MedicineUniversity of SaskatchewanSaskatoonCanada

Bibliographic information