Cytokine Knockouts

  • Giamila Fantuzzi

Part of the Contemporary Immunology book series (CONTIM)

Table of contents

  1. Front Matter
    Pages i-xix
  2. Cytokine Knockouts in Models of Human Disease

    1. Front Matter
      Pages 1-1
    2. Pietro Ghezzi
      Pages 3-10
    3. Alfons Billiau, Hubertine Heremans, Patrick Matthys
      Pages 33-55
    4. Robert H. Wiltrout, Jon M. Wigginton, William J. Murphy
      Pages 57-71
    5. Giamal N. Luheshi, Emmanuel Pinteaux, Hervé Boutin
      Pages 73-92
  3. Cytokine Knockout Mice

    1. Front Matter
      Pages 93-93
    2. Susumu Nakae, Reiko Horai, Yutaka Komiyama, Aya Nambu, Masahide Asano, Akio Nakane et al.
      Pages 95-109
    3. Martin J. H. Nicklin, Joanna Shepherd
      Pages 111-134
    4. Thomas Hünig, Anneliese Schimpl
      Pages 135-149
    5. Ferenc Olosz, Thomas R. Malek
      Pages 151-170
    6. Thomas Enzler, Glenn Dranoff
      Pages 171-186
    7. Pascale Kropf, Ingrid Müller
      Pages 187-202
    8. Paul S. Foster, Simon P. Hogan
      Pages 203-211
    9. Valeria Poli, Diego Maritano
      Pages 213-235
    10. Karen L. Madsen, Humberto Jijon
      Pages 237-251
    11. Luciano Adorini
      Pages 253-268
    12. Duncan R. Hewett, Andrew N. J. McKenzie
      Pages 269-280
    13. Pallavur V. Sivakumar, Sandra N. Brown, Ananda W. Goldrath, Anne Renee Van der Vuurst de Vries, Joanne L. Viney, Mary K. Kennedy
      Pages 281-301
    14. Hiroko Tsutsui, Tomohiro Yoshimoto, Haruki Okamura, Shizuo Akira, Kenji Nakanishi
      Pages 303-322
    15. Jane M. Schuh, Steven L. Kunkel, Cory M. Hogaboam
      Pages 323-345
    16. Dyana Dalton
      Pages 347-359
    17. Gunter Fingerle-Rowson, Abhay E. Satoskar, Richard Bucala
      Pages 361-378
    18. Susan R. Rittling, Anthony W. O’Regan, Jeffrey S. Berman
      Pages 379-393
    19. Young-Yun Kong, Josef M. Penninger
      Pages 395-419
    20. Lawrence Wolfraim, Mizuko Mamura, Anita Roberts, John J. Letterio
      Pages 421-438
    21. Sergei A. Nedospasov, Sergei I. Grivennikov, Dmitry V. Kuprash
      Pages 439-460
  4. Back Matter
    Pages 461-471

About this book


Carrying on the high standards of the much-praised first edition (Durum and Muegge, Cytokine Knockouts, 1998), Giamila Fantuzzi and a panel of experts have generated completely new chapters to reflect the use of many novel mouse strains and the hundreds of recent studies on cytokine physiology. Comprehensive reviews of the numerous, often surprising results obtained using cytokine knockout mice are provided, along with much important information about cytokine biology. For those not familiar with cytokine research, in part I the authors present a critical discussion of the advantages and disadvantages of using cytokine knockout mice in various fields of research. In their discussion of research methodology and data interpretation, the writers stress the need for caution when trying to interpret data, especially when these may affect clinical practice, and the danger of forgetting the possible effects of redundancy and of unspecified perturbations in the immune system when a single gene is deleted. Chapters dealing with mice deficient for single cytokines and/or cytokine receptors are presented in part II.
Cutting-edge and highly instructive, Cytokine Knockouts, Second Edition illuminates for researchers today both the usefulness of cytokine knockout mice to study a wide variety of cytokine phenomena and the possible complications of such studies.


Chemokine Immune System autoimmune disease migration physiology

Editors and affiliations

  • Giamila Fantuzzi
    • 1
  1. 1.University of Colorado Health Sciences CenterDenverUSA

Bibliographic information