Essentials of Apoptosis

A Guide for Basic and Clinical Research

  • Xiao-Ming Yin
  • Zheng Dong

Table of contents

  1. Front Matter
    Pages i-x
  2. Molecules and Pathways of Apoptosis

    1. Front Matter
      Pages 1-1
    2. Brona M. Murphy, Seamus J. Martin
      Pages 3-12
    3. Xiao-Ming Yin, Wen-Xing Ding, Yongge Zhao
      Pages 13-27
    4. Peter Liston, Wai Gin Fong, Robert G. Korneluk
      Pages 29-46
    5. Maria Eugenia Guicciardi, Gregory J. Gores
      Pages 67-84
    6. Bruno Antonsson
      Pages 85-99
    7. Marja Jäättelä, Marcel Leist
      Pages 101-122
  3. Apoptosis in Action

    1. Front Matter
      Pages 123-123
    2. Ron Mittler, Vladimir Shulaev
      Pages 125-133
    3. Yi-Chun Wu, Ding Xue
      Pages 135-144
    4. Sujin Bao, Ross L. Cagan
      Pages 145-161
    5. Chia-Yi Kuan, Keisuke Kuida
      Pages 163-175
    6. Sean L. O’Connor, Fermin Briones, Nikhil S. Chari, Song H. Cho, Rebecca L. Hamm, Yoshihiko Kadowaki et al.
      Pages 177-199
    7. J. John Cohen, Maria D. Devore, Mile Cikara, Elizabeth A. Dowling
      Pages 201-210
    8. R. Anne Stetler, Jun Chen
      Pages 211-224
    9. Zheng Dong, Manjeri A. Venkatachalam
      Pages 225-236
  4. Approaches to the Study of Apoptosis

    1. Front Matter
      Pages 237-237
    2. Li Bai, Jinzhao Wang, Xiao-Ming Yin, Zheng Dong
      Pages 239-251
  5. Back Matter
    Pages 253-259

About this book


Recent apoptosis research has revealed the process' complex molecular and biochemical mechanisms, even as it has also complicated its study, particularly when trying to generalize findings from multiple laboratories or applying methods used in one context to another system. In Essentials of Apoptosis: A Guide for Basic and Clinical Research, experienced investigators have systematically compiled a comprehensive but concise summary of essential, up-to-date information about apoptosis. The authors present the concepts, the molecular architecture, the biochemical pathways, and the pathophysiological significance of apoptosis. In addition, standard biochemical and cell biologic approaches to apoptosis research are described as a guideline for bench work, with clinical applications detailed for immune disorders, cancer, ischemia/reperfusion injury, and neuronal degeneration. Coverage extends to a broad range of biological systems, from bacteria, plants, worms, and fruit flies to mammals.
Comprehensive and highly instructive, Essentials of Apoptosis: A Guide for Basic and Clinical Research systematically presents the core concepts of apoptosis, providing both a user-friendly introduction for those new to the field and an up-to-date reference for established researchers seeking an integrated understanding of apoptosis and new avenues for its productive investigation.


Activation Drosophila apoptosis bacteria biology cancer cell programmed cell death structural biology

Editors and affiliations

  • Xiao-Ming Yin
    • 1
  • Zheng Dong
    • 2
  1. 1.Department of PathologyUniversity of Pittsburgh School of MedicinePittsburghUSA
  2. 2.Department of Cellular Biology and AnatomyMedical College of GeorgiaAugustaUSA

Bibliographic information