Genetics and Genomics of Neurobehavioral Disorders

  • Gene S. Fisch

Part of the Contemporary Clinical Neuroscience book series (CCNE)

Table of contents

  1. Front Matter
    Pages i-x
  2. Introduction and Overview

    1. Front Matter
      Pages 1-1
    2. Albert M. Galaburda, J. Eric Schmitt
      Pages 21-37
    3. Rui M. Costa, Ype Elgersma, Alcino J. Silva
      Pages 39-68
  3. Autosomal Disorders and Neurobehavioral Dysfunction

    1. Front Matter
      Pages 95-95
    2. Nancy Ratner, Kathryn North
      Pages 97-131
    3. Elisabeth M. Dykens, Suzanne B. Cassidy
      Pages 133-158
    4. Julian R. Sampson, Julia C. Lewis
      Pages 159-194
    5. Mònica Bayés, Luis A. Pérez Jurado
      Pages 209-236
  4. X-Linked Nonsyndromal Disorders and Neurobehavioral Dysfunction

    1. Front Matter
      Pages 261-261
    2. Jamel Chelly, Ben C. J. Hamel
      Pages 263-287
  5. X-Linked Syndromal Disorders and Neurobehavioral Dysfunction

    1. Front Matter
      Pages 307-307
    2. Takahito Wada, Richard J. Gibbons
      Pages 309-334
    3. Mark C. Hirst, Gene S. Fisch
      Pages 335-389
    4. Alan K. Percy, Joanna Dragich, N. Carolyn Schanen
      Pages 391-418
  6. Back Matter
    Pages 419-428

About this book


In recent years, significant gains have been made in the cloning and identification of numerous genes that produce neurobehavioral disorders, as well as in the ability of neuropsychological tests to accurately assess and evaluate cognitive deficits and behavioral dysfunction. In Genetics and Genomics of Neurobehavioral Disorders, a panel of leading researchers draws on this new knowledge to provide a clear and comprehensive account of how genetic abnormalities, neurobiology, and neuropsychology work together to manifest cognitive-behavioral dysfunction. The authors review the current status of research in autosomal disorders that produce such dysfunctions, examining both microdeletion disorders (Prader-Willi syndrome/Angelman syndrome, deletion 22q11, and Williams syndrome) and syndromes arising from microdeletions and sequence variants, among them neurofibromatosis (NF1 and NF2), tuberous sclerosis (TSC1 and TSC2), and myotonic dystrophy. X-linked disorders producing mental retardation in syndromal disorders (ATRX, Rett, and fragile X) and nonsyndromal disorders (FRAXE and MRX) are also discussed. An insightful introduction surveys the history of neurobehavioral disorders, the establishment of relationships between genetic and cognitive impairment, the relationship between neurobiology and behavior, recent advances in neurogenomics, and the use of animal models for complex human disorders and cognitive impairment.
Comprehensive and up-to-date, Genetics and Genomics of Neurobehavioral Disorders integrates the molecular, genomic, neuropsychological, and neurobehavioral factors that produce learning disabilities and mental retardation into a coherent framework for the understanding and assessment of neurobehavioral disorders.


Nervous System Syndrom genes genetics neurobiology neuropsychology

Editors and affiliations

  • Gene S. Fisch
    • 1
  1. 1.Division of Biostatistics, Department of Epidemiology and Public Health and the Child Study CenterYale University School of MedicineNew HavenUSA

Bibliographic information