© 2003

Type 1 Diabetes

Etiology and Treatment

  • Mark A. Sperling

Part of the Contemporary Endocrinology book series (COE)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Etiology

    1. Front Matter
      Pages 1-1
    2. Janice S. Dorman, Ronald E. LaPorte, Thomas J. Songer
      Pages 3-22
    3. Massimo Pietropaolo, Massimo Trucco
      Pages 23-54
    4. Aristides K. Maniatis, George S. Eisenbarth
      Pages 55-70
    5. Åke Lernmark, Choon Hee Chung
      Pages 71-92
    6. Tiinamaija Tuomi, Jaakko Perheentupa
      Pages 93-114
    7. Nicolai M. Doliba, Franz M. Matschinsky
      Pages 115-144
    8. Philip E. Cryer
      Pages 145-161
    9. Timothy G. Barrett
      Pages 163-179
  3. Treatment of Type 1 Diabetes

    1. Front Matter
      Pages 181-181
    2. Ram K. Menon, Mark A. Sperling
      Pages 183-198
    3. Baiju R. Shah, Bernard Zinman
      Pages 199-213
    4. Jean Betschart Roemer, Linda Siminerio
      Pages 249-260
    5. Christine A. Beebe
      Pages 261-276
  4. Special Management Issues in Type 1 Diabetes

    1. Front Matter
      Pages 277-277
    2. Nadia Tubiana-Rufi, Paul Czernichow
      Pages 279-292
    3. William V. Tamborlane, Elizabeth A. Boland, Margaret Grey
      Pages 293-305

About this book


The increasing incidence of diabetes worldwide has prompted a rapid growth in the pace of scientific discovery and clinical understanding of this enigmatic disease. In Type 1 Diabetes: Etiology and Treatment, well-recognized physicians and researchers review the latest thinking about the causes of this condition and the best approaches to treating both its acute and chronic complications. The treatment options discussed range from life-threatening diabetic ketoacidosis to contemporary insulin regimens, from open- and closed-loop insulin delivery devices to modern glucose-sensing mechanisms, as well as such daily life issues as nutrition and education. Also discussed are the management of children under the age of five, the special problems of preadolescents and adolescents, diabetic surgery, and pregnancy, along with the treatment and prevention of the long-term vascular complications that produce coronary artery disease, the loss of limbs, end-stage renal disease, and blindness. The authors pay special attention to explaining the molecular basis of diabetes and its complications, as well as to the many recent developments in whole pancreas and islet cell transplantation, including the means for avoiding the rejection of transplanted islets.
Authoritative and up-to-date, Type 1 Diabetes: Etiology and Treatment provides all those caring for diabetic patients with a concise, accessible survey of today's best thinking about the causes, treatment, and management of this complex disease.


Diabetes Insulin Secretion Pancreas growth factor insulin metabolic control

Editors and affiliations

  • Mark A. Sperling
    • 1
    • 2
  1. 1.Department of PediatricsUniversity of Pittsburgh School of MedicinePittsburghUSA
  2. 2.Division of EndocrinologyChildren’s Hospital of PittsburghPittsburghUSA

Bibliographic information

  • Book Title Type 1 Diabetes
  • Book Subtitle Etiology and Treatment
  • Editors Mark A. Sperling
  • Series Title Contemporary Endocrinology
  • DOI
  • Copyright Information Humana Press 2003
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-0-89603-931-5
  • Softcover ISBN 978-1-61737-258-2
  • eBook ISBN 978-1-59259-310-1
  • Edition Number 1
  • Number of Pages XIII, 593
  • Number of Illustrations 61 b/w illustrations, 7 illustrations in colour
  • Topics Diabetes
  • Buy this book on publisher's site


"The first section provides a sound discussion of our understanding of the etiology of the disease, providing the reader with an excellent working knowledge to assess possible future prevention strategies. The clinical chapters are well organized, authored by known experts, and provide excellent summaries of cutting edge management. The final chapters devoted to islet transplantation and the relevant scientific issues are timely and enlightening...This entry in the Contemporary Endocrinology series represents a uniquely accessible overview of the current scientific and clinical frontiers relevant to type 1 diabetes mellitus. By providing an understanding of where immunological knowledge will likely lead and what current therapy should entail, this book provides an opportunity for both clinical and research specialists to better understand each other's fields." -Doody's Health Sciences Book Review Journal

"A highly recommended book that is hard to put down. It was easy to read, detailed, and extremely useful in a practical sense for clinicians." - E-Streams

"The complex interactions of genetics, autoimmunity, and insulin secretion are covered thoroughly and would gainfully challenge most experts in the field." -Annals of Internal Medicine