Microbial DNA and Host Immunity

  • Eyal Raz

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Eyal Raz
      Pages 3-8
    3. Saburo Yamamoto, Toshiko Yamamoto, Tohru Tokunaga
      Pages 9-14
  3. Receptors and Signaling

    1. Front Matter
      Pages 15-15
    2. Hiroaki Hemmi, Shizuo Akira
      Pages 39-47
    3. Wen-Ming Chu, Xing Gong, Tony Yoon
      Pages 49-61
    4. Katryn J. Stacey, David P. Sester, Shalin Naik, Tara L. Roberts, Matthew J. Sweet, David A. Hume
      Pages 63-77
  4. Cell Activation

    1. Front Matter
      Pages 79-79
    2. Saburo Yamamoto, Toshiko Yamamoto, Tetsuro Kataoka, Sumiko Iho, Tohru Tokunaga
      Pages 81-89
    3. David Askew, Rose S. Chu, Clifford V. Harding
      Pages 91-101
    4. Ae-Kyung Yi, Arthur M. Krieg
      Pages 103-127
    5. Hearn Jay Cho, Sandip Datta, Eyal Raz
      Pages 137-149
  5. Vaccination Strategies

    1. Front Matter
      Pages 151-151
    2. Maripat Corr, Chih Min Tang
      Pages 153-162
    3. Hiroko Kobayashi, Elena Martin-Orozco, Kenji Takabayashi, Anthony A. Horner
      Pages 163-174
    4. Kenji Takabayashi, Helen Tighe, Lucinda Beck, Hans L. Spiegelberg
      Pages 175-188
    5. Eli Kedar, Igal Louria-Hayon, Aviva Joseph, Zichria Zakay-Rones, Tomoko Hayashi, Kenji Takabayashi et al.
      Pages 203-218
    6. Christina C. N. Wu, Chih Min Tang, Brian Crain, Maripat Corr
      Pages 219-226
  6. Applications—Infectious Diseases

    1. Front Matter
      Pages 227-227
    2. Michael J. McCluskie, Risini D. Weeratna, Heather L. Davis
      Pages 229-238
    3. Sandip K. Datta, Anthony A. Horner, Kenji Takabayashi, Eyal Raz
      Pages 239-254
    4. Dennis M. Klinman, Ken J. Ishii, Ihsan Gursel
      Pages 255-263
    5. Tomoko Hayashi, Christine H. Tran, Lucinda Beck, Savita Rao, Antonino Catanzaro
      Pages 265-275
  7. Applications—Allergy

    1. Front Matter
      Pages 277-277
    2. Anthony A. Horner, Eyal Raz
      Pages 279-287
    3. Reid K. Ikeda, Kenji Takabayashi, David Broide
      Pages 289-299
    4. Kunihiko Kitagaki, Joel N. Kline
      Pages 301-314
  8. Applications—Cancer

    1. Front Matter
      Pages 327-327
    2. Thomas L. Warren, George J. Weiner
      Pages 329-337
  9. Inflammation and Autoimmunity

    1. Front Matter
      Pages 339-339
    2. David S. Pisetsky
      Pages 341-350
    3. Andrej Tarkowski, L. Vincent Collins, Guo-Min Deng, Lena Mölne
      Pages 351-361
    4. Sarah T. A. Roord, Arash Ronaghy, Berent J. Prakken, Kenji Takabayashi, Dennis A. Carson
      Pages 363-371
    5. Daniel Rachmilewitz, Fanny Karmeli, Leonor Leider-Trejo, Kenji Takabayashi, Tomoko Hayashi, Eyal Raz
      Pages 373-381
  10. Safety Considerations

    1. Front Matter
      Pages 383-383
    2. Daniela Verthelyi, Dennis M. Klinman
      Pages 385-396
  11. Back Matter
    Pages 397-408

About this book


The immunostimulatory prospects of bacterial DNA have attracted the interest and attention of scientists and physicians and become a major focus in immunobiology and biomedicine. These activities are the product of immunostimulatory DNA sequences (ISS, also known as GpG motifs), which are rare in the mammalian genome. ISS were shown to enhance immunological responses and were used to confer protection to a wide variety of tumors, allergic inflammation, and infections. In Microbial DNA and Host Immunity, leading researchers review the activation of the mammalian immune system by bacterial DNA and consider the applications of ISS in clinical medicine. The authors survey the latest findings concerning the receptor-recognition and signaling pathways triggered by ISS, the process of cell activation, and potential vaccination strategies using ISS. Specific pharmaceutical applications discussed include infectious disease (Hepatitis B, HIV, and mycobacterial infections), allergy (asthma and conjunctivitis), cancer (lymphoma), and inflammation and autoimmunity (arthritis and colitis).
Up-to-date and informative, Microbial DNA and Host Immunity illuminates the immunobiology of bacterial DNA and its promise of powerful new vaccines to provide protective immunity against infections, tumors, and chronic disease.


Antigen Asthma DNA HIV Nucleotide infections infectious disease

Editors and affiliations

  • Eyal Raz
    • 1
  1. 1.University of California, San DiegoLa JollaUSA

Bibliographic information