Forensic and Clinical Applications of Solid Phase Extraction

  • Michael J. Telepchak
  • Thomas F. August
  • Glynn Chaney

Part of the Forensic Science and Medicine book series (FSM)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Michael J. Telepchak, Thomas F. August, Glynn Chaney
    Pages 1-39
  3. Michael J. Telepchak, Thomas F. August, Glynn Chaney
    Pages 41-53
  4. Michael J. Telepchak, Thomas F. August, Glynn Chaney
    Pages 55-62
  5. Michael J. Telepchak, Thomas F. August, Glynn Chaney
    Pages 63-90
  6. Michael J. Telepchak, Thomas F. August, Glynn Chaney
    Pages 91-107
  7. Michael J. Telepchak, Thomas F. August, Glynn Chaney
    Pages 109-128
  8. Michael J. Telepchak, Thomas F. August, Glynn Chaney
    Pages 129-146
  9. Michael J. Telepchak, Thomas F. August, Glynn Chaney
    Pages 147-168
  10. Michael J. Telepchak, Thomas F. August, Glynn Chaney
    Pages 169-244
  11. Michael J. Telepchak, Thomas F. August, Glynn Chaney
    Pages 245-279
  12. Michael J. Telepchak, Thomas F. August, Glynn Chaney
    Pages 281-295
  13. Michael J. Telepchak, Thomas F. August, Glynn Chaney
    Pages 297-309
  14. Back Matter
    Pages 311-370

About this book

Introduction

Solid phase extraction (SPE) has become a powerful and extensively used technique in the clean up and concentration of samples for analysis in a wide variety of analytical techniques. In Forensic and Clinical Applications of Solid Phase Extraction, hands-on experts explain the principles behind SPE and provide a host of readily reproducible protocols designed to allow the reader to master his or her extraction challenges with little or no additional help. These detailed methods are particularly suited to solving extraction problems in forensic and clinical chemistry and include readily understandable explanations of such complicated ideas as the principles of pH, ion exchange, and copolymeric mechanism-enhanced SPE. Numerous actual chromatograms, based on original research and from diverse applications, demonstrate the technique and the results that can be achieved. The applications are grouped by drug types and matrices. Extensive appendices allow fast access to frequently needed information on reagents, the preparation of solutions and buffers, milliequivalent and millimode calculations, buffers and pKa for SPE, and a complete RapidTrace® technical manual. Each proven protocol is described in step-by-step detail and contains an introduction outlining the principle behind the technique, lists of equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
State-of-the-art and highly practical, Forensic and Clinical Applications of Solid Phase Extraction is a complete laboratory reference manual that will give forensic and clinical chemists at any level of expertise the ability to make clean extractions with high recoveries and effectively enhance their analytical problem-solving skills.

Keywords

chemistry drug research toxicology

Authors and affiliations

  • Michael J. Telepchak
    • 1
  • Thomas F. August
    • 1
  • Glynn Chaney
    • 1
  1. 1.United Chemical Technologies Inc.BristolUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-59259-292-0
  • Copyright Information Humana Press 2004
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-61737-114-1
  • Online ISBN 978-1-59259-292-0
  • About this book