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Gene Engineering in Endocrinology

  • Margaret A. Shupnik

Part of the Contemporary Endocrinology book series (COE, volume 22)

Table of contents

  1. Front Matter
    Pages i-x
  2. Growth, Development, and Metabolism

    1. Front Matter
      Pages N1-N1
    2. Michael J. Quon, Simeon I. Taylor
      Pages 17-38
    3. Andrew P. Bradford, Arthur Gutierrez-Hartmann
      Pages 39-65
    4. Bryan R. Haugen, David F. Gordon, William M. Wood
      Pages 67-86
    5. Uma R. Chandran, Donald B. DeFranco
      Pages 87-97
    6. Jung-Hsin Hsu, Gregory A. Brent
      Pages 119-133
    7. Ronald N. Cohen, Fredric E. Wondisford
      Pages 135-151
    8. Mark W. Nachtigal, Debra Enyeart-VanHouten, Holly A. Ingraham
      Pages 153-166
  3. Reproductive System

    1. Front Matter
      Pages N3-N3
    2. T. Rajendra Kumar, Martin M. Matzuk
      Pages 167-216
    3. Veronica Soloveva, Jiandie Lin, Grace T. Ma, Daniel I. H. Linzer
      Pages 307-322
    4. Derek A. Schreihofer, Eileen M. Resnick, Margaret A. Shupnik
      Pages 407-426
  4. Back Matter
    Pages 427-433

About this book

Introduction

Recent advances in genetic engineering and molecular biology have made it possible to disrupt specific genes in order to determine and better understand their function and clinical significance. In Gene Engineering in Endocrinology, Margaret Shupnik and a team of leading investigators review the most recent breakthroughs, emphasizing how studies of natural mutations and gene knockouts have illuminated endocrine processes. Using both animal and human model data, these authoritative researchers examine in depth the molecular basis of development, growth, and reproductive processes, the specific mutations that explain certain genetic syndromes, the hormonal regulation of gene expression (which affects the treatment of infertility and steroid-dependent cancers), and current research directions. When possible, molecular studies are compared with naturally occurring human and animal gene mutations to establish the difference between complete elimination of, or an altered, gene function.
Comprehensive and up-to-date, Gene Engineering in Endocrinology offers today's experimental and clinical endocrinologists, as well as reproductive biologists, a richly informative survey of what has already been accomplished with the genetic engineering of hormone processes and hormone-related genetic syndromes-research that promises powerful new experimental and therapeutic opportunities as this field continues it rapid development.

Keywords

Gonadotropin glucocorticoid hormone receptors insulin nuclear receptors signaling pathways thyroid hormone

Editors and affiliations

  • Margaret A. Shupnik
    • 1
  1. 1.Division of Endocrinology, Department of Internal MedicineUniversity of Virginia Health Sciences CenterCharlottesvilleUSA

Bibliographic information