Folate and Human Development

  • Edward J. Massaro
  • John M. Rogers

Table of contents

  1. Front Matter
    Pages i-xii
  2. Nicholas D. E. Greene, Andrew J. Copp
    Pages 1-26
  3. Manuela Födinger, Sonja Skoupy, Gere Sunder-Plassmann
    Pages 91-115
  4. Barton A. Kamen
    Pages 117-135
  5. Tom K. A. B. Eskes
    Pages 137-163
  6. Robert C. Barber, Janée van Waes, Edward J. Lammer, Gary M. Shaw, Thomas H. Rosenquist, Richard H. Finnell
    Pages 165-181
  7. A. Katherine Herbig, Patrick J. Stover
    Pages 241-262
  8. Tom K. A. B. Eskes
    Pages 299-328
  9. Jayne V. Woodside, Ian S. Young
    Pages 329-344
  10. Back Matter
    Pages 345-359

About this book


Folic acid not only helps to prevent a variety of serious neural-tube birth defects-among them anencephaly and spina bifida-but is also an important factor in general human health. In Folate and Human Development, an authoritative panel of basic and clinical researchers critically reviews the latest findings on the role of folate in human development, health, and disease. Specific areas addressed include folate metabolism in zinc or copper deficiencies, choline and folate in development, animal models of folate-related birth defects, developmental toxicants potentially acting via folate perturbation, and folate's role in vascular disease in women. There are also cutting-edge discussions of genes and neural tube development, folate receptor polymorphism and the risk for neural defects, abnormal DNA synthesis and methylation with folate/methyl insufficiency, and folic acid and homocysteine as risk factors for neural-tube defects.
Comprehensive and up-to-date, Folate and Human Development critically evaluates our current understanding of the role of folates in human health and disease, offering biomedical and clinical researchers a deeper understanding of the folate and nutrient basis of neural-tube defects.


DNA Vitamin Vitamin B12 genetics metabolism

Editors and affiliations

  • Edward J. Massaro
    • 1
  • John M. Rogers
    • 1
  1. 1.The National Health and Environmental Effects Research LaboratoryResearch Triangle ParkUSA

Bibliographic information