Thrombolytic Therapy for Stroke

  • Patrick D. Lyden

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Background and Basic Investigations

    1. Front Matter
      Pages 1-1
    2. Gregory J. del Zoppo, Naohisa Hosomi
      Pages 3-27
    3. Patrick D. Lyden
      Pages 43-62
  3. Scientific Rationale and Clinical Trials

    1. Front Matter
      Pages 63-63
    2. Anne M. Guyot, Steven R. Levine
      Pages 65-74
    3. Anne M. Guyot, Luchi Quinones, Steven R. Levine
      Pages 91-127
    4. Rashmi U. Kothari, Joseph P. Broderick
      Pages 141-152
    5. Susan C. Fagan, Thomas Kwiatkowski, Patrick Lyden
      Pages 153-174
    6. Anthony J. Furlan, Randall Higashida, Irene Katzan, Alex Abou-Chebl
      Pages 175-195
    7. Joseph Broderick, Rashmi Kothari
      Pages 197-208
  4. Using Thrombolysis for Acute Stroke

    1. Front Matter
      Pages 209-209
    2. Christopher Lewandowski
      Pages 237-253
    3. Rüdiger von Kummer
      Pages 255-282
    4. John Marler, Patrick D. Lyden
      Pages 297-308
  5. Illustrative Cases

    1. Patrick D. Lyden
      Pages 311-398
  6. Back Matter
    Pages 399-410

About this book


Tissue plasminogen activator (t-PA) is the only treatment currently proven to benefit stroke victims, but no physician guide to its safe and proper use exists. In Thrombolytic Therapy for Stroke, the world's leading experts detail the basic rationale, scientific evidence, and treatment protocol for thrombolytic therapy in acute stroke patients. These experienced clinicians show how promptly delivered thrombolysis can restore cerebral blood flow in time to salvage brain and neurologic function, first by reviewing the preclinical development of thrombolytics, and then by presenting the pivotal clinical trials that proved their efficacy and safety. Their description of the treatment protocol discusses field triage and management, emergency department therapy, brain imaging, clinical decision making and patient selection, drug administration, post--thrombolysis management, and the treatment of complications. Real-life programmed case histories-complete with commentary and brain images-illustrate the use of the thrombolytic therapy protocol and illuminate its special indications and contraindications.
Comprehensive and highly practical, Thrombolytic Therapy for Stroke offers the practicing physician everything necessary-background, protocols, and case studies-for the safe and effective treatment of the emergency stroke patient today.


artery brain brain imaging ischemic stroke stroke

Editors and affiliations

  • Patrick D. Lyden
    • 1
  1. 1.UCSD Stroke CenterSan DiegoUSA

Bibliographic information