Neuroglia in the Aging Brain

  • Jean S. de Vellis

Part of the Contemporary Neuroscience book series (CNEURO)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Cellular and Molecular Changes of Aged and Reactive Astrocytes

    1. Front Matter
      Pages 1-1
    2. Maria Angeles Peinado, Manuel Martinez, Maria Jesus Ramirez, Adoracion Quesada, Juan Angel Pedrosa, Concepcion Iribar et al.
      Pages 3-16
    3. Sudarshan K. Malhotra, Theodor K. Shnitka
      Pages 17-33
    4. Jesús Boya, J. L. Calvo, Angel López-Carbonell, José E. García-Mauriño
      Pages 35-56
  3. Neuron-Glia Intercommunication

    1. Front Matter
      Pages 57-57
    2. Marilee K. Shelton, Ken D. McCarthy
      Pages 59-76
    3. Brigitte Hamon, Jacques Glowinski, Christian Giaume
      Pages 99-112
    4. Elizabeth A. Howes, Peter J. S. Smith
      Pages 113-134
    5. Thierry Amédée, Aurore Colomar, Jonathan A. Coles
      Pages 135-153
  4. Neurotrophins, Growth Factors, and Neurohormones in Aging and Regeneration

    1. Front Matter
      Pages 155-155
    2. Gérard Labourdette, Françoise Eclancher
      Pages 157-178
    3. Zezong Gu, J. Regino Perez-Polo
      Pages 217-244
    4. Kevin Higashigawa, Alisa Seo, Nayan Sheth, Giorgios Tsianos, Hogan Shy, Latha Malaiyandi et al.
      Pages 245-256
  5. Metabolic Changes

    1. Front Matter
      Pages 257-257
    2. Michael Aschner, Richard M. LoPachin
      Pages 259-274
    3. Neville Brookes
      Pages 275-288
  6. Astrocytes and the Blood-Brain Barrier in Aging

    1. Front Matter
      Pages 289-289
    2. Dorothee Krause, Pedro M. Faustmann, Rolf Dermietzel
      Pages 291-303
    3. Gesa Rascher, Hartwig Wolburg
      Pages 305-320
  7. Astrocytes in Neurodegenerative Diseases

    1. Front Matter
      Pages 337-337
    2. Douglas G. Walker, Thomas G. Beach
      Pages 339-363
    3. Kurt R. Brunden, Robert C. A. Frederickson
      Pages 365-374
    4. Miguel Lafarga, Nuria T. Villagra, Maria T. Berciano
      Pages 375-392
    5. Catherine Mytilineou
      Pages 407-419
    6. Angélique Bordey, Harald Sontheimer
      Pages 421-441
    7. Michael D. Norenberg
      Pages 477-496
  8. Back Matter
    Pages 497-513

About this book


With the proportion of the aged in the population rapidly increasing, especially those 80 and beyond, it has become imperative to understand not only how to prevent and treat the disabilities and diseases of old age, and to prolong and improve functional ability. The biology of neuroglia has thus emerged as one of the most exciting research areas in the neurosciences. In Neuroglia in the Aging Brain, Jean de Vellis and a distinguished panel of internationally recognized neuroscientists comprehensively review the involvement of and changes in glial cells both during the normal aging process and in the major disorders of old age. Topics range from the cellular and molecular changes that occur with aging-especially aging-associated gliosis in astrocytes and its relation to neuronal injury and repair-to neuron-glia intercommunication. The contributors show how glial signals may be modulated by hormones, growth factors, neurotransmitters, intracellular metabolism, and intercellular exchanges, as well as by aging of the blood-brain barrier. Also discussed is the role of the neuroglia, especially of the astrocytes and microglia, in the etiology of several neurodegenerative diseases, as well as the possibilities for therapeutic interventions in glial responses, and indirectly on neurons.
Illuminating and multidisciplinary, Neuroglia in the Aging Brain provides today's neuroscientists and neuropathologists with powerful new insights into how glial cells are involved in the pathogenesis of major aging disorders and how they may be used therapeutically to encourage neuronal self-renewal.


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Editors and affiliations

  • Jean S. de Vellis
    • 1
  1. 1.UCLA Mental Retardation Research CenterLos AngelesUSA

Bibliographic information