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The Genetics of Osteoporosis and Metabolic Bone Disease

  • Michael J. Econs

Table of contents

  1. Front Matter
    Pages i-xi
  2. Serge Ferrari, René Rizzoli, Jean-Philippe Bonjour
    Pages 45-60
  3. Stuart H. Ralston
    Pages 61-74
  4. Paul A. Dawson, Joan C. Marini
    Pages 75-93
  5. Sachiko Kitanaka, Shigeaki Kato
    Pages 95-110
  6. Michael J. Econs, Kenneth E. White
    Pages 111-132
  7. Kandaswamy Jayaraj, Kenneth Lyles
    Pages 153-161
  8. Eileen M. Shore, John G. Rogers, Roger Smith, Francis H. Gannon, Martin Delatycki, J. Andoni Urtizberea et al.
    Pages 211-236
  9. Rajesh V. Thakker
    Pages 275-294
  10. Frederick R. Singer, Robin J. Leach
    Pages 309-318
  11. L. Lyndon Key Jr.
    Pages 319-333
  12. Michael P. Whyte
    Pages 335-356
  13. Harald Jüppner, Caroline Silve
    Pages 357-376
  14. Suzanne M. Leal, Marcy C. Speer
    Pages 377-413
  15. Fiona Francis, Tim M. Strom
    Pages 415-429
  16. Peter S. N. Rowe
    Pages 431-446
  17. Back Matter
    Pages 447-462

About this book

Introduction

Great strides have been made through molecular biology in uncovering the genetic component of many illnesses that until recently were not considered genetic disorders. In The Genetics of Osteoporosis and Metabolic Bone Disease, Michael J. Econs and a distinguished team of internationally renowned experts summarize and review these advances in the understanding of osteoporosis and metabolic bone disease. Topics range from an examination of the genetic contributions to osteoporosis and the many factors that must be considered when searching for genes that predispose to osteoporosis, to recent advances in the clinical and molecular biological aspects of inherited metabolic disorders. The diseases covered are both single gene (Mendelian) traits-such as X-linked hypophosphatemic rickets-and such complex disorders as osteoporosis and Paget's disease. The book includes a discussion of current methodology for finding genes that predispose to metabolic bone diseases.
Authoritative and state-of-the-art, The Genetics of Osteoporosis and Metabolic Bone Disease offers today's endocrinologists, rheumatologists, and geneticists a gold-standard compendium of current knowledge and thinking about the genetic disorders of bone and mineral metabolism, and a sound basis for the powerful new genetic therapies.

Keywords

Osteogenesis imperfecta genes genetics homeostasis hormone resistance signaling system thyroid hormone

Editors and affiliations

  • Michael J. Econs
    • 1
  1. 1.Departments of Medicine and Medical and Molecular GeneticsIndiana University School of MedicineIndianapolisUSA

Bibliographic information