Cerebral Signal Transduction

From First to Fourth Messengers

  • Maarten E. A. Reith

Part of the Contemporary Neuroscience book series (CNEURO)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Maarten E. A. Reith
      Pages 3-23
  3. Memory

    1. Front Matter
      Pages 25-25
    2. Matthew Lattal, Ted Abel
      Pages 27-71
    3. Eddy A. Van der Zee, Bas R. K. Douma, John F. Disterhoft, Paul G. M. Luiten
      Pages 105-125
  4. Neurodegeneration and Apoptosis

    1. Front Matter
      Pages 127-127
    2. Masayuki Sasaki, Valina L. Dawson, Ted M. Dawson
      Pages 151-174
    3. Carl W. Cotman, Haoyu Qian, Aileen J. Anderson
      Pages 175-205
    4. Aase Frandsen, Jette Bisgaard Jensen, Arne Schousboe
      Pages 207-220
  5. Depression

    1. Front Matter
      Pages 221-221
    2. Robert M. Post, Susan R. B. Weiss, Li-Xin Zhang, M. Guoqiang Xing
      Pages 249-281
    3. Peter P. Li, Stavroula Andreopoulos, Jerry J. Warsh
      Pages 283-309
  6. Drug Dependence

    1. Front Matter
      Pages 311-311
    2. Rafael Maldonado, Olga Valverde
      Pages 313-339
    3. Kimberly Scearce-Levie, René Hen
      Pages 341-373
    4. Deborah C. Mash, Li Chen Kramer, David Segal, Sari Izenwasser
      Pages 401-417
  7. Back Matter
    Pages 419-428

About this book


In Cerebral Signal Transduction: From First to Fourth Messengers, Maarten E.A. Reith and a team of leading experts comprehensively review and synthesize the most recent advances in our understanding of the role of cerebral signaling in neuronal and cerebral function. The authors emphasize the functional role of the various signaling pathways in memory, apoptosis and degeneration, depression, and drug dependence in both health and diseases states. The signaling pathways discussed include cAMP/PKA, Ca2+/calmodulin-dependent protein kinase, DAG/PKG, and neurotrophic factor signaling cascades. By taking full advantage of the newfound ability to selectively remove, reduce, or enhance specific components of the signaling pathways, the investigators writing here illuminate the varied signaling cascades, their crosstalk, and the many possibilities for changes in gene expression underlying long-term changes in brain function.
Cutting-edge and comprehensive, Cerebral Signal Transduction: From First to Fourth Messengers advances our understanding of the mechanistic underpinnings of complex behavioral processes and clinically relevant brain diseases. A major contribution to the development of the novel pharmacotherapeutics targeting downstream events in the cascade of second, third, and fourth messengers, it will serve experimental and clinical neuroscientists as today's best and most complete guide to neuronal signaling.


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Editors and affiliations

  • Maarten E. A. Reith
    • 1
  1. 1.College of MedicineUniversity of IllinoisPeoriaUSA

Bibliographic information