Vascular Disease and Injury

Preclinical Research

  • Daniel I. Simon
  • Campbell Rogers

Part of the Contemporary Cardiology book series (CONCARD)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Acute Mechanical Injury and Vascular Repair

    1. Front Matter
      Pages 1-1
    2. Frederick G. P. Welt, Elazer R. Edelman, Campbell Rogers
      Pages 3-17
    3. Robert S. Schwartz, Birgit Kantor, David R. Holmes Jr.
      Pages 19-41
    4. Andrew J. Carter
      Pages 43-51
    5. Mark Nedelman, Christopher Horvath, Campbell Rogers
      Pages 53-60
    6. Afshin Ehsan, Michael J. Mann, Victor J. Dzau
      Pages 61-78
    7. Zhiping Chen, Campbell Rogers, Daniel I. Simon
      Pages 87-94
    8. Daniel T. Eitzman, Randal J. Westrick
      Pages 95-101
    9. Ernane D. Reis, Susan S. Smyth, Barry S. Coller
      Pages 103-113
  3. Models of Arterial Thrombosis

  4. Chronic Atherosclerotic Models

    1. Front Matter
      Pages 147-147
    2. Wulf Palinski, Claudio Napoli, Peter D. Reaven
      Pages 149-174
    3. Masanori Aikawa, Yoshihiro Fukumoto, Elena Rabkin, Peter Libby
      Pages 175-191
    4. David Kritchevsky, Robert J. Nicolosi
      Pages 193-204
  5. Vascular Disease in Transplanted Vessels

    1. Front Matter
      Pages 205-205
    2. Victor Chengwei Shi, Jennifer L. Hoover
      Pages 207-214
    3. Richard N. Mitchell
      Pages 215-229
    4. Raymond H. Chen, David H. Adams
      Pages 231-243
  6. Vascular Disease in Models of Arterial Hypertension

  7. Animal Care and Tissue Processing

    1. Front Matter
      Pages 301-301
    2. Robert P. Marini
      Pages 303-323
    3. Philip Seifert, Campbell Rogers, Elazer R. Edelman
      Pages 325-338
  8. Back Matter
    Pages 339-347

About this book


The development of effective cardiovascular therapeutics to treat or prevent atherosclerosis and restenosis relies on preclinical research using animal models. In Vascular Disease and Injury: Preclinical Studies, a panel of expert clinical researchers offers a practical guide to the key animal models used in vascular disease research. These experts examine critical issues related to vascular disease and injury in five major areas: acute mechanical injury and vascular repair, arterial thrombosis, chronic atherosclerosis, vascular disease in transplanted vessels, and vascular disease in systemic and pulmonary arterial hypertension. Each practically oriented chapter includes equipment lists; current sources for animals, diet, and reagents; schematic diagrams; and, when pertinent, photomicrographs of sample histology. Key points regarding survival strategy, choice of anesthetic and analgesia, and veterinary issues are also provided, as are the basic histopathologic methods for tissue harvesting, fixation, and electron microscopy preparation.
Up-to-date and highly practical, Vascular Disease and Injury: Preclinical Studies provides a comprehensive review that not only illuminates the current status of cardiovascular research, but also offers vascular biologists and cardiologists a detailed how-to guide to the development of the many powerful new therapeutics now emerging.


Stent anesthesia atherosclerosis cardiovascular hypertension thrombosis transplantation vascular disease

Editors and affiliations

  • Daniel I. Simon
    • 1
  • Campbell Rogers
    • 1
  1. 1.Cardiovascular DivisionBrigham and Women’s HospitalBostonUSA

Bibliographic information