Toxicologic Pathology for Non-Pathologists

  • Thomas J. Steinbach
  • Daniel J. Patrick
  • Mary Ellen Cosenza

Table of contents

  1. Front Matter
    Pages i-x
  2. George A. Parker
    Pages 1-44
  3. Ted A. Birkebak, Peter C. Mann
    Pages 45-77
  4. Pamela Blackshear, Erica Carroll, Sasmita Mishra, Matthew Renninger, Arun Tatiparthi
    Pages 79-112
  5. Robert R. Maronpot, David E. Malarkey
    Pages 113-136
  6. Mark J. Hoenerhoff, Arun Kumar R. Pandiri
    Pages 137-199
  7. Kendall S. Frazier
    Pages 201-250
  8. Juliana S. Lee, Sarah D. Cramer, Mark T. Butt
    Pages 251-277
  9. Joshua H. Decker, Radhakrishna Sura, Paul W. Snyder
    Pages 279-309
  10. Jack R. Harkema, James G. Wagner
    Pages 311-354
  11. Tracey L. Papenfuss, Marlon C. Rebelatto, Brad Bolon
    Pages 355-395
  12. Kelly L. Diegel, Lars Mecklenburg, Lydia Andrews-Jones, David F. Adams
    Pages 483-535
  13. Brent E. Walling, Thomas J. Rosol
    Pages 537-569
  14. Stacey L. Fossey, D. Greg Hall, Andrew W. Suttie, Martin Guillot, Aurore Varela
    Pages 571-618
  15. Leandro B. C. Teixeira
    Pages 619-659
  16. Kenneth A. Schafer
    Pages 661-688
  17. Adam Aulbach, Laura Cregar
    Pages 689-743
  18. Paul Howroyd
    Pages 745-778
  19. Catherine A. Picut, Amera K. Remick
    Pages 779-849
  20. Shannon M. Wallace, Jeffrey C. Wolf
    Pages 851-873
  21. Kelly L. Diegel, Lars Mecklenburg, Lydia Andrews-Jones, David F. Adams
    Pages C1-C1
  22. Back Matter
    Pages 875-919

About this book


This extensive volume began as a short course primarily geared toward toxicologists who want to expand their understanding of toxicologic pathology in order to be better study directors while also proving to be of great interest to other drug development scientists and regulatory reviewers. The overall goal is to help non-pathologists understand, contextualize, and communicate the pathology data and interpretations from the study pathologist in a practical and usable format. Within the book, readers will find an overview of general pathology concepts that include fundamental vocabulary and the basics of pathophysiological processes, along with numerous chapters devoted to pathology in specific organ systems as well as topics such as biomarkers, correlation of clinical pathology endpoints (chemistry and hematology) with microscopic changes, and well-known pathology findings for classes of toxic substances. 

Authoritative, practical, and comprehensive, Toxicologic Pathology for Non-Pathologists aims to help non-pathologists understand, converse in, and apply a basic understanding of pathology in their day-to-day careers.


Study design Toxic substances Tissue collection Organ systems Animal models Toxicology Pathology data communication

Editors and affiliations

  • Thomas J. Steinbach
    • 1
  • Daniel J. Patrick
    • 2
  • Mary Ellen Cosenza
    • 3
  1. 1.North Carolina LaboratoryExperimental Pathology Laboratories, Inc.DurhamUSA
  2. 2.Charles River Laboratories, Inc.MattawanUSA
  3. 3.MEC Regulatory and Toxicology Consulting, LLCMoorparkUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC, part of Springer Nature 2019
  • Publisher Name Humana, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-9776-3
  • Online ISBN 978-1-4939-9777-0
  • Buy this book on publisher's site