Biophysics of RNA-Protein Interactions

A Mechanistic View

  • Chirlmin Joo
  • David Rueda

Part of the Biological and Medical Physics, Biomedical Engineering book series (BIOMEDICAL)

Table of contents

  1. Front Matter
    Pages i-vii
  2. RNA Binding Proteins

    1. Front Matter
      Pages 1-1
    2. Rajan Lamichhane
      Pages 3-21
    3. Lin Huang, David M. J. Lilley
      Pages 23-37
    4. Jaya Sarkar, Jong Chan Lee, Sua Myong
      Pages 39-55
  3. Transcription and Translation

    1. Front Matter
      Pages 107-107
    2. Eugen Ostrofet, Flavia Stal Papini, Anssi M. Malinen, David Dulin
      Pages 109-141
  4. RNA-Guided Protein Machineries

    1. Front Matter
      Pages 165-165
    2. Luuk Loeff, Chirlmin Joo
      Pages 189-210
    3. Mohamed Fareh
      Pages 211-249

About this book


RNA molecules play key roles in all aspects of cellular life, but to do so efficiently, they must work in synergism with proteins. This book addresses how proteins and RNA interact to carry out biological functions such as protein synthesis, regulation of gene expression, genome defense, liquid phase separation and more.

The topics addressed in this volume will appeal to researchers in biophysics, biochemistry and structural biology. The book is a useful resource for anybody interested in elucidating the molecular mechanisms and discrete properties of RNA-protein complexes. Included are reviews of key systems such as microRNA and CRISPR/Cas that exemplify how RNA and proteins work together to perform their biological function. Also covered are techniques ranging from single molecule fluorescence and force spectroscopy to crystallography, cryo-EM microscopy, and kinetic modeling.


Biophysical characterization methods David Rueda NMR spectroscopy Protein interactions RNA-protein interactions Ribonuclear complexes

Editors and affiliations

  • Chirlmin Joo
    • 1
  • David Rueda
    • 2
  1. 1.Kavli Institute of NanoScienceDelft University of TechnologyDelftThe Netherlands
  2. 2.Department of MedicineImperial College LondonLondonUK

Bibliographic information