Non-Natural Nucleic Acids

Methods and Protocols

  • Nathaniel Shank

Part of the Methods in Molecular Biology book series (MIMB, volume 1973)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Stella Diafa, Damien Evéquoz, Christian J. Leumann, Marcel Hollenstein
    Pages 1-13
  3. Na An, Aaron M. Fleming, Nicole C. Rosecrans, Yi Liao, Cynthia J. Burrows
    Pages 15-25
  4. Petra Ménová, Hana Cahová, Milan Vrábel, Michal Hocek
    Pages 39-57
  5. Tanaya Bose, Vaijayanti A. Kumar
    Pages 91-106
  6. Bappaditya Nandi, Sankha Pattanayak, Sibasish Paul, Jayanta Kundu, Surajit Sinha
    Pages 107-130
  7. Nathaniel Shank, Kara M. George Rosenker, Ethan A. Englund, Andrew V. Dix, Elizabeth E. Rastede, Daniel H. Appella
    Pages 131-145
  8. Derrick Watkins, Krishnagopal Maiti, Dev P. Arya
    Pages 147-162
  9. Igor G. Panyutin
    Pages 185-191
  10. Michael P. Ledbetter, Denis A. Malyshev, Floyd E. Romesberg
    Pages 193-212
  11. Renatus W. Sinkeldam, Yitzhak Tor
    Pages 251-260
  12. Keiji Murayama, Hiromu Kashida, Hiroyuki Asanuma
    Pages 261-279
  13. Timofei S. Zatsepin, Anna M. Varizhuk, Vladimir G. Dedkov, German A. Shipulin, Andrey V. Aralov
    Pages 281-297
  14. Back Matter
    Pages 313-315

About this book


This volume provides relevant synthetic strategies, incorporation, and applications of non-natural nucleic acids. Chapters detail monomer synthesis, oligomer synthesis/construction, and applications allowing researchers to explore and determine which methodology or methodologies are relevant to their needs.  Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Authoritative and cutting-edge, Non-Natural Nucleic Acids: Methods and Protocols aims to serve as a guide for researchers exploring their own inquiries and to provide a springboard for new endeavors.


Non-natural DNA mimics Nanoscaffolds Bioorganic chemistry Site-specific labeling DNA

Editors and affiliations

  • Nathaniel Shank
    • 1
  1. 1.Department of Chemistry and BiochemistryGeorgia Southern UniversitySavannahUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC, part of Springer Nature 2019
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-9215-7
  • Online ISBN 978-1-4939-9216-4
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site