Developmental Toxicology

Methods and Protocols

  • Jason M. Hansen
  • Louise M. Winn

Part of the Methods in Molecular Biology book series (MIMB, volume 1965)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Omar J. Mohammed, Margaret K. Pratten
    Pages 49-72
  3. France-Hélène Paradis, Han Yan, Chunwei Huang, Barbara F. Hales
    Pages 73-91
  4. Jone A. Stanley, Joe A. Arosh, Patricia B. Hoyer, Sakhila K. Banu
    Pages 107-127
  5. Kathryn Bambino, Joshua Morrison, Jaime Chu
    Pages 129-138
  6. Michael R. Stark, Micah M. Ross
    Pages 155-171
  7. Emily W. Y. Tung, Louise M. Winn
    Pages 187-194
  8. Craig Harris
    Pages 195-217
  9. Terence R. S. Ozolinš
    Pages 219-233
  10. Brendon K. Warner, Jonathan K. Alder, Arminda Suli
    Pages 235-250
  11. Danielle M. Drake, Peter G. Wells
    Pages 351-374
  12. Robert E. Seegmiller, Nathan Cook, Korance Goodwin, Timothy Leishman, Michelle Graf
    Pages 421-434
  13. Back Matter
    Pages 435-436

About this book


This thorough edition explores numerous methodological approaches that can be extremely informative for our understanding of the developmental toxicant mechanisms, characterization of developmental outcomes, and development of potential interventions that are clinically relevant. Presenting both staple and state-of-the-art approaches, the book focuses on numerous cellular models (induced pluripotent stem cells, neural crest culture, etc.), some less frequently used but important animal models (chick, zebrafish), in vitro approaches using whole embryos (rat, mouse and rabbit), and specific outcome methodologies to assess changes on the morphological to molecular level. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and expert implementation advice that allows for smooth processes in the lab. 

Authoritative and practical, Developmental Toxicology: Methods and Protocols, Second Edition serves as an ideal aid to support further investigation into the specific mechanisms and outcomes of developmental exposures.


In utero exposures Fetal basis of disease Toxicant mechanisms Toxicity Embryology Prenatal exposure Cellular models Animal models

Editors and affiliations

  • Jason M. Hansen
    • 1
  • Louise M. Winn
    • 2
  1. 1.Department of Physiology and Developmental BiologyBrigham Young UniversityProvoUSA
  2. 2.Biomedical and Molecular SciencesQueen’s UniversityKingstonCanada

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC, part of Springer Nature 2019
  • Publisher Name Humana, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-9181-5
  • Online ISBN 978-1-4939-9182-2
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site