Bioinformatics and Drug Discovery

  • Richard S. Larson
  • Tudor I. Oprea

Part of the Methods in Molecular Biology book series (MIMB, volume 1939)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Translational Bioinformatics in Drug Discovery

    1. Front Matter
      Pages 1-1
    2. Melike Cokol-Cakmak, Murat Cokol
      Pages 3-9
    3. Paul Shinn, Lu Chen, Marc Ferrer, Zina Itkin, Carleen Klumpp-Thomas, Crystal McKnight et al.
      Pages 11-35
    4. Jason Bret Harris
      Pages 37-47
    5. Hande Küçük McGinty, Ubbo Visser, Stephan Schürer
      Pages 49-69
  3. Informatics in Drug Discovery

    1. Front Matter
      Pages 71-71
    2. Helen V. Cook, Lars Juhl Jensen
      Pages 73-89
    3. Benjamin S. Glicksberg, Li Li, Rong Chen, Joel Dudley, Bin Chen
      Pages 91-118
    4. Cristian G. Bologa, Oleg Ursu, Tudor I. Oprea
      Pages 119-138
    5. Robert D. Clark, Pankaj R. Daga
      Pages 139-159
    6. Shawn T. Phillips, James N. Dodds, Jody C. May, John A. McLean
      Pages 161-178
  4. Clinical Research Informatics in Drug Discovery

    1. Front Matter
      Pages 179-179
    2. Ioannis N. Melas, Theodore Sakellaropoulos, Junguk Hur, Dimitris Messinis, Ellen Y. Guo, Leonidas G. Alexopoulos et al.
      Pages 181-198
    3. Parveen Bansal, Malika Arora, Vikas Gupta, Mukesh Maithani
      Pages 215-230
    4. Si Zheng, Shazia Dharssi, Meng Wu, Jiao Li, Zhiyong Lu
      Pages 231-252
  5. Clinical Informatics in Drug Discovery

  6. Back Matter
    Pages 323-324

About this book


This third edition volume expands on the previous editions with new topics that cover drug discovery through translational bioinformatics, informatics, clinical research informatics, as well as clinical informatics. The chapters discuss new methods to study target identification, genome analysis, cheminformatics, protein analysis, and text mining. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials, software workflows, reagents and on-line resources, together with step-by-step, readily reproducible laboratory and computational protocols, and tips on troubleshooting and avoiding known pitfalls.

Cutting-edge and thorough, Bioinformatics and Drug Discovery, Third Edition is a valuable resource for anyone interested in drug design, including academicians (biologists, informaticists and data scientists, chemists, and biochemists), clinicians, and pharmaceutical scientists.


Translational bioinformatics Informatics Clinical research informatics Data mining Computational approaches drug discovery

Editors and affiliations

  • Richard S. Larson
    • 1
  • Tudor I. Oprea
    • 2
  1. 1.Department of PathologyUniversity of New MexicoAlbuquerqueUSA
  2. 2.Department of Internal MedicineUniversity of New MexicoAlbuquerqueUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC, part of Springer Nature 2019
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-9088-7
  • Online ISBN 978-1-4939-9089-4
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site