Cancer Driver Genes

Methods and Protocols

  • Timothy K. Starr

Part of the Methods in Molecular Biology book series (MIMB, volume 1907)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Christopher R. Clark, Wilaiwan DuRose, Timothy K. Starr
    Pages 1-15
  3. Cancer Gene Discovery In Silico Based on Sequencing Data

  4. Cancer Gene Discovery Using Cell and Organoid Systems

    1. Front Matter
      Pages 81-81
    2. Raffaele Hellweg, Ashley Mooneyham, Martina Bazzaro
      Pages 83-90
    3. Charles H. Adelmann, Tim Wang, David M. Sabatini, Eric S. Lander
      Pages 125-136
    4. Nicholas J. Slipek, Jyotika Varshney, David A. Largaespada
      Pages 137-144
    5. Kathryn A. O’Donnell, Yabin Guo, Shruthy Suresh, Barrett L. Updegraff, Xiaorong Zhou
      Pages 145-157
  5. Cancer Gene Discovery Using Animal Models

    1. Front Matter
      Pages 159-159
    2. Kelsie L. Becklin, Branden A. Smeester, Branden S. Moriarity
      Pages 161-170
    3. Mathias J. Friedrich, Iraad F. Bronner, Pentao Liu, Allan Bradley, Roland Rad
      Pages 171-183
  6. Back Matter
    Pages 213-214

About this book


This book presents protocols for identification of genetic drivers of cancer. Chapters guide readers through a brief history of cancer gene discovery, in silico approaches, in vitro approaches, and in vivo approaches using forward genetic screens in mice. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and cutting-edge, Cancer Driver Genes: Methods and Protocols aims to provide protocols that will be used and adapted by cancer researchers to expand the knowledge base of molecular mechanisms contributing to initiation, progression, and metastasis of cancer.




throughput sequencing CNAs MAXDRIVER Bioinformatic CRISPR

Editors and affiliations

  • Timothy K. Starr
    • 1
  1. 1.Masonic Cancer CenterUniversity of Minnesota Medical SchoolMinneapolisUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC, part of Springer Nature 2019
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-8966-9
  • Online ISBN 978-1-4939-8967-6
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site