Methods and Protocols

  • Andrew Bateman
  • Hugh P.J. Bennett
  • Siu Tim Cheung

Part of the Methods in Molecular Biology book series (MIMB, volume 1806)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Andrew Bateman, Siu Tim Cheung, Hugh P. J. Bennett
      Pages 3-15
  3. Analytical and In Vitro Methods for the Study of Progranulin Biology

  4. Methods to Investigate the Role of Progranulin in Cancer

    1. Front Matter
      Pages 93-93
    2. Shi-Qiong Xu, Simone Buraschi, Ryuta Tanimoto, Manuela Stefanello, Antonino Belfiore, Renato V. Iozzo et al.
      Pages 121-130
    3. Chi Wai Yip, Phyllis F. Y. Cheung, Nicholas C. L. Wong, Sze Wai Fung, Siu Tim Cheung
      Pages 131-144
  5. Animal Models to Study the Role of Progranulin in Health and Disease

    1. Front Matter
      Pages 177-177
    2. Babykumari P. Chitramuthu, Hugh P. J. Bennett
      Pages 207-231
    3. Xiaolai Zhou, Peter M. Sullivan, Daniel H. Paushter, Fenghua Hu
      Pages 269-288
    4. Laura Diaz-Cueto, Fabian Arechavaleta-Velasco, George L. Gerton
      Pages 289-304
  6. Back Matter
    Pages 361-363

About this book


This volume explores experimental strategies to study progranulin as a regulatory protein in biological and disease processes. The chapters in this book are divided into four parts: Part One is an introduction to the topic; Part Two looks at analytical and in vitro methods to study progranulin biology; Part Three discusses the role of progranulin in cancer; and Part Four describes the process of using animal models to study progranulin in health and disease. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Cutting-edge and thorough, Progranulin: Methods and Protocols is a valuable resource for experienced researchers who want to expand their studies of this field, and newcomers who want to begin including progranulin into their work.”


granulin polypeptides granulin-epithelin precursor (GEP) acrogranin PC cell-derived growth factor (PCDGF) neurodegenerative diseases animal models sortilin

Editors and affiliations

  • Andrew Bateman
    • 1
  • Hugh P.J. Bennett
    • 2
  • Siu Tim Cheung
    • 3
  1. 1.Department of MedicineMcGill University MUHCMontrealCanada
  2. 2.Department of MedicineMcGill University MUHCMontrealCanada
  3. 3.Department of SurgeryThe Chinese University of Hong KongHong KongChina

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC, part of Springer Nature 2018
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-8557-9
  • Online ISBN 978-1-4939-8559-3
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site