Genetic Epidemiology

Methods and Protocols

  • Evangelos Evangelou

Part of the Methods in Molecular Biology book series (MIMB, volume 1793)

Table of contents

  1. Front Matter
    Pages i-x
  2. Lazaros Belbasis, Vanesa Bellou
    Pages 1-6
  3. Kalliope Panoutsopoulou, Eleanor Wheeler
    Pages 7-24
  4. Kalliope Panoutsopoulou, Klaudia Walter
    Pages 25-36
  5. Abbas Dehghan
    Pages 37-49
  6. Karoline Kuchenbaecker, Emil Vincent Rosenbaum Appel
    Pages 51-71
  7. Kyriaki Michailidou
    Pages 73-88
  8. Andrew T. DeWan
    Pages 89-110
  9. Loukas Moutsianas, Javier Gutierrez-Achury
    Pages 111-134
  10. Raha Pazoki
    Pages 145-156
  11. Niki L. Dimou, Katerina G. Pantavou, Georgia G. Braliou, Pantelis G. Bagos
    Pages 157-182
  12. Panagiota I Kontou, Athanasia Pavlopoulou, Pantelis G. Bagos
    Pages 183-210
  13. Aurélien Macé, Zoltán Kutalik, Armand Valsesia
    Pages 231-258
  14. Karol Estrada, Alzheimer’s Disease Neuroimaging Initiative
    Pages 277-290
  15. Back Matter
    Pages 291-299

About this book


This volume details fast-moving research while providing in-depth descriptions of methods and analytical approaches that are helping to understand the genome and how it is related to complex diseases. Chapters guide the reader through common and rare variation, gene-gene and gene-environment interactions and state-of-the-art approaches for the synthesis of genome-wide and gene expression data. Novel approaches for associations in the HLA region, family-based designs, Mendelian Randomization and Copy Number Variation are also presented.  The volume concludes with the challenges researchers face while moving from identifying variants to their functional role and potential drug targets. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, a thorough presentation of methods and approaches and tips on troubleshooting and avoiding known pitfalls.


Genome variation Multivariate genetic epidemiology polygenic traits Mendelian Randomization

Editors and affiliations

  • Evangelos Evangelou
    • 1
  1. 1.Department of Hygiene and EpidemiologyUniversity of Ioannina Medical SchoolIoanninaGreece

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC, part of Springer Nature 2018
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-7867-0
  • Online ISBN 978-1-4939-7868-7
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site