Methods and Protocols

  • Franck Pellestor

Part of the Methods in Molecular Biology book series (MIMB, volume 1769)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Genesis and Impact of Chromothripsis

    1. Front Matter
      Pages 1-1
    2. Alessio Marcozzi, Franck Pellestor, Wigard P. Kloosterman
      Pages 3-19
    3. Franck Pellestor
      Pages 43-49
  3. The Identification of Chromothripsis

    1. Front Matter
      Pages 51-51
    2. Veronica Ortega, Christina Mendiola, Gopalrao V. N. Velagaleti
      Pages 85-117
    3. Isabelle M. Henry, Luca Comai, Ek Han Tan
      Pages 119-132
    4. Anne-Laure Bougé, Florence Rufflé, Sébastien Riquier, Benoit Guibert, Jérôme Audoux, Thérèse Commes
      Pages 133-156
  4. The Causal Mechanisms of Chromothripsis

    1. Front Matter
      Pages 157-157
    2. Dustin C. Hancks
      Pages 169-181
    3. Monique N. H. Luijten, Jeannie X. T. Lee, Sixun Chen, Karen C. Crasta
      Pages 183-195
    4. Oumar Samassekou, Nathalie Bastien, Ju Yan, Sabine Mai, Régen Drouin
      Pages 209-230
    5. Oumar Samassekou, Nathalie Bastien, Ju Yan, Sabine Mai, Régen Drouin
      Pages 253-262
  5. The Bioinformatic Tools for Chromothripsis Analysis

  6. The Experimental Models

    1. Front Matter
      Pages 291-291
    2. Christine J. Ye, Guo Liu, Henry H. Heng
      Pages 337-352
    3. Kevin Yauy, Vincent Gatinois, Thomas Guignard, Satish Sati, Jacques Puechberty, Jean Baptiste Gaillard et al.
      Pages 353-361
  7. Back Matter
    Pages 363-367

About this book


This detailed book presents an up-to-date view on methods and experimental approaches developed to identify and explore the chromothripsis phenomenon. Beginning with a section exploring the genesis and impact of chromothripsis, the collection continues by covering the identification of chromothripsis, the causal mechanisms of chromothripsis, the bioinformatics tools for chromothripsis analysis, and experimental systems recently developed for the in vitro investigation of chromothripsis. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Authoritative and practical, Chromothripsis: Methods and Protocols serves as a vital resource for cell biologists, molecular biologists, cytogeneticists, and geneticists investigating chromothripsis, but also for students and researchers new to the field of chromothripsis and genomic instability.


Massive genomic alterations DNA fragments Complex derivative chromosomes Cytogenetics Bioinformatics Cancer research

Editors and affiliations

  • Franck Pellestor
    • 1
  1. 1.Unit of Chromosomal Genetics, Department of Medical GeneticsCHU MontpellierMontpellierFrance

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC, part of Springer Nature 2018
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-7779-6
  • Online ISBN 978-1-4939-7780-2
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site