Cellular Heterogeneity

Methods and Protocols

  • Natasha S. Barteneva
  • Ivan A. Vorobjev

Part of the Methods in Molecular Biology book series (MIMB, volume 1745)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. General

    1. Front Matter
      Pages 1-1
    2. Albert Gough, Tong Ying Shun, D. Lansing Taylor, Mark Schurdak
      Pages 25-46
    3. Katherin Patsch, Shannon M. Mumenthaler, Daniel Ruderman
      Pages 47-63
  3. Cytometry in Cellular Heterogeneity Research

    1. Front Matter
      Pages 65-65
    2. Tess Melinda Brodie, Vinko Tosevski
      Pages 67-82
    3. Veronika Dashkova, Jeff Clapper, Ivan A. Vorobjev, Natasha S. Barteneva
      Pages 83-95
    4. Andrew M. Crawford, James E. Penner-Hahn
      Pages 97-112
    5. Sara A. Mathie, Alastair L. Corbin, Hayley L. Eames, Irina A. Udalova
      Pages 113-124
    6. Ekaterina Kopeikina, Marina Dukhinova, Eugene D. Ponomarev
      Pages 155-166
  4. Imaging and Spectroscopy Methods in Heterogeneity Studies

    1. Front Matter
      Pages 179-179
    2. Anara Serikbaeva, Anna Tvorogova, Sholpan Kauanova, Ivan A. Vorobjev
      Pages 181-204
    3. Aleena Gladkikh, Anastasia Kovaleva, Anna Tvorogova, Ivan A. Vorobjev
      Pages 205-218
  5. Metabolic and Molecular Biological Methods in Cell Heterogeneity Tracking

  6. Chromatin and Cell Cycle Heterogeneity

    1. Front Matter
      Pages 303-303
    2. Elizaveta Fasler-Kan, Nijas Aliu, Kerstin Wunderlich, Sylvia Ketterer, Sabrina Ruggiero, Steffen Berger et al.
      Pages 305-314
    3. Daria M. Potashnikova, Sergey A. Golyshev, Alexey A. Penin, Maria D. Logacheva, Anna V. Klepikova, Anastasia A. Zharikova et al.
      Pages 315-335
    4. Scott Gladstein, Andrew Stawarz, Luay M. Almassalha, Lusik Cherkezyan, John E. Chandler, Xiang Zhou et al.
      Pages 337-360
  7. Back Matter
    Pages 361-363

About this book


This volume is essential for anyone struggling with the cellular heterogeneity field, and it connects this new area with the latest advances in innovative techniques combined with practical advice from international experts. The chapters provide a comprehensive overview of cellular heterogeneity analysis techniques, exploring cytometry, imaging and spectroscopy methods, metabolic and molecular biological methods in tracking, as well as chromatin and cell cycle heterogeneity. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, detailed lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. 

Authoritative and accessible, Cellular Heterogeneity: Methods and Protocols encourages readers to explore new ways of studying cells that will help lead to exciting new discoveries.


Live cell imaging Cytometric data Cell population 3D cell cultures Flow cytometry Heterogeneity tracking Chromatin

Editors and affiliations

  • Natasha S. Barteneva
    • 1
  • Ivan A. Vorobjev
    • 2
  1. 1.PCMM-Harvard Medical SchoolBoston Children’s HospitalBostonUSA
  2. 2.Department of Biology, School of Sciences and TechnologyNazarbayev UniversityAstanaKazakhstan

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2018
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-7679-9
  • Online ISBN 978-1-4939-7680-5
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site