Proteases and Cancer

Methods and Protocols

  • Santiago Cal
  • Alvaro J. Obaya

Part of the Methods in Molecular Biology book series (MIMB, volume 1731)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Ángel Álvarez-Eguiluz, Ander Díaz-Navarro, Xose S. Puente
    Pages 1-13
  3. Keiji Kikuchi, Hiroko Kozuka-Hata, Masaaki Oyama, Motoharu Seiki, Naohiko Koshikawa
    Pages 29-37
  4. Vladimir Leksa, Herbert B. Schiller, Hannes Stockinger
    Pages 39-47
  5. Salvatore Santamaria, Hideaki Nagase
    Pages 107-122
  6. Tania Fontanil, Yamina Mohamedi, Santiago Cal, Álvaro J. Obaya
    Pages 133-143
  7. María Ángeles Villaronga, Saúl Álvarez Teijeiro, Francisco Hermida-Prado, Marta Garzón-Arango, Victoria Sanz-Moreno, Juana María García-Pedrero
    Pages 145-154
  8. Shishir M. Pant, Denis Belitskin, Hanna Ala-Hongisto, Juha Klefström, Topi A. Tervonen
    Pages 169-178
  9. Francisco Javier Rodríguez-Baena, Silvia Redondo-García, María del Carmen Plaza-Calonge, Rubén Fernández-Rodríguez, Juan Carlos Rodríguez-Manzaneque
    Pages 179-192
  10. Álvaro Sahún-Español, Cristina Clemente, Alicia G. Arroyo
    Pages 193-212
  11. Pirjo Åström, Ritva Heljasvaara, Pia Nyberg, Ahmed Al-Samadi, Tuula Salo
    Pages 213-221
  12. Maureen Van de Velde, Melissa García-Caballero, Tania Durré, Frédéric Kridelka, Agnès Noël
    Pages 223-233
  13. Alicia R. Folgueras, Sandra Freitas-Rodríguez, Yaiza Español, Gloria Velasco
    Pages 235-245
  14. Anupama Pal, Alnawaz Rehemtulla
    Pages 247-260
  15. Julia M. Fraile, Diana Campos-Iglesias, José M. P. Freije
    Pages 261-269
  16. Sergio Alonso, Beatriz González, Andreu Alibés, Manuel Perucho
    Pages 271-294
  17. Joseph S. Bednash, Rama K. Mallampalli
    Pages 295-305
  18. Dong Hyun Nam, Xin Ge
    Pages 307-324
  19. Zoi Piperigkou, Dimitra Manou, Konstantina Karamanou, Achilleas D. Theocharis
    Pages 325-348
  20. Back Matter
    Pages 349-352

About this book


This volume explores the role of proteases in various catalytic classes and cellular processes associated with cancer. The chapters in this book cover topics such as encoding proteolytic enzymes, cleavage sites of proteases, functional catalytic domains of MMPs, zymography,  angiogenesis and lymphangiogenesis, genetic and epigenetic alterations of metallopeptidases, and methods to target metalloproteinases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Comprehensive and cutting edge, Proteases and Cancer: Methods and Protocols is a valuable resource for clinical researchers across numerous fields such as molecular and cellular biology, oncology, biochemistry, and chemistry. This book is also useful for PhD students in the various disciples of health sciences.


degradomes protease substrates lysosomes ubiquitin-proteasome neoplastic transformation

Editors and affiliations

  • Santiago Cal
    • 1
  • Alvaro J. Obaya
    • 2
  1. 1.Instituto Universitario de Oncología (IUOPA)Universidad de OviedoOviedoSpain
  2. 2.Instituto Universitario de Oncología (IUOPA)Universidad de OviedoOviedoSpain

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2018
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-7594-5
  • Online ISBN 978-1-4939-7595-2
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site