The Retinoblastoma Protein

  • Pedro G. Santiago-Cardona

Part of the Methods in Molecular Biology book series (MIMB, volume 1726)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Thaís M. McCormick, Maria Da Glória Da C. Carvalho
    Pages 29-34
  3. Sumadi Lukman Anwar, Ulrich Lehmann
    Pages 35-47
  4. Pedro G. Santiago-Cardona, Jaileene Pérez-Morales, Jonathan González-Flores
    Pages 49-64
  5. Charles A. Ishak, Matthew J. Cecchini, Christopher J. Howlett, Frederick A. Dick
    Pages 65-75
  6. Jaileene Pérez-Morales, Angel Núñez-Marrero, Pedro G. Santiago-Cardona
    Pages 77-84
  7. Margit Balázs, Viktória Koroknai, István Szász, Szilvia Ecsedi
    Pages 85-100
  8. Javed Hussain Choudhury, Raima Das, Shaheen Laskar, Sharbadeb Kundu, Manish Kumar, Partha Pratim Das et al.
    Pages 111-122
  9. Georgia Karpathiou, Michel Peoc’h
    Pages 123-142
  10. Miyoung Lee, Lorraine J. Gudas, Harold I. Saavedra
    Pages 143-151
  11. Ainhoa Iglesias-Ara, Nerea Osinalde, Ana M. Zubiaga
    Pages 153-166
  12. Manishkumar Pandey, Priyanka G. Bhosale, Manoj B. Mahimkar
    Pages 167-175
  13. Thomas Naert, Kris Vleminckx
    Pages 177-193
  14. Back Matter
    Pages 195-200

About this book


This volume covers the mechanisms of pRb inactivation detailing repressive mechanisms commonly associated to cancer, and representative of the experimentally relevant tests used in the establishment of cancer diagnosis and prognosis. Chapters contain protocols and in-depth discussions for commonly used experimental approaches to assess the status and function of components of the pRb pathway, including pRb itself, in cell lines and biological samples.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, The Retinoblastoma Protein aims to serve as a guide to assist molecular cancer biologists in their search for understanding of the molecular functions of this preeminent tumor suppressor.


RB1 gene Fluorescence in situ hypermethylation small interfering RNAs human tumor tissue

Editors and affiliations

  • Pedro G. Santiago-Cardona
    • 1
  1. 1.Biochemistry and Cancer Biology Divisions Basic Science DepartmentPonce Health Sciences UniversityPoncePuerto Rico

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2018
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-7564-8
  • Online ISBN 978-1-4939-7565-5
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site