Genome Instability

Methods and Protocols

  • Marco Muzi-Falconi
  • Grant W Brown

Part of the Methods in Molecular Biology book series (MIMB, volume 1672)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Carolina A. Novoa, J. Sidney Ang, Peter C. Stirling
    Pages 1-9
  3. Anjana Srivatsan, Christopher D. Putnam, Richard D. Kolodner
    Pages 43-61
  4. Monica Ransom, D. Suzi Bryan, Jay R. Hesselberth
    Pages 63-76
  5. Patrick van Eijk, Yumin Teng, Mark R. Bennet, Katie E. Evans, James R. Powell, Richard M. Webster et al.
    Pages 77-99
  6. Sarah Sertic, Stefania Roma, Paolo Plevani, Federico Lazzaro, Marco Muzi-Falconi
    Pages 101-105
  7. Vincent Pagès, Robert P. Fuchs
    Pages 107-118
  8. Matteo Ferrari, Shyam Twayana, Federica Marini, Achille Pellicioli
    Pages 119-129
  9. Chiara Vittoria Colombo, Luca Menin, Michela Clerici
    Pages 131-145
  10. Pablo Huertas, Andrés Cruz-García
    Pages 147-154
  11. Laura Baranello, Fedor Kouzine, Damian Wojtowicz, Kairong Cui, Keji Zhao, Teresa M. Przytycka et al.
    Pages 155-166
  12. Reza Mirzazadeh, Tomasz Kallas, Magda Bienko, Nicola Crosetto
    Pages 167-194
  13. Xanita Saayman, Cristina Ramos-Pérez, Grant W. Brown
    Pages 195-207
  14. Andrea Keszthelyi, Izumi Miyabe, Katie Ptasińska, Yasukazu Daigaku, Karel Naiman, Antony M. Carr
    Pages 239-259
  15. Nicolai B. Larsen, Ian D. Hickson, Hocine W. Mankouri
    Pages 295-309
  16. Barbara Kind, Christine Wolf, Kerstin Engel, Alexander Rapp, M. Cristina Cardoso, Min Ae Lee-Kirsch
    Pages 311-318
  17. Alice Meroni, Giulia M. Nava, Sarah Sertic, Paolo Plevani, Marco Muzi-Falconi, Federico Lazzaro
    Pages 319-327
  18. Clinton D. Orebaugh, Scott A. Lujan, Adam B. Burkholder, Anders R. Clausen, Thomas A. Kunkel
    Pages 329-345
  19. María García-Rubio, Sonia I. Barroso, Andrés Aguilera
    Pages 347-361
  20. Diego Bonetti, Maria Pia Longhese
    Pages 363-373
  21. David Guérit, Maxime Lalonde, Pascal Chartrand
    Pages 387-402
  22. Erica J. Polleys, Catherine H. Freudenreich
    Pages 403-419
  23. Elina A. Radchenko, Ryan J. McGinty, Anna Y. Aksenova, Alexander J. Neil, Sergei M. Mirkin
    Pages 421-438
  24. Victoria A. Bjerregaard, Özgün Özer, Ian D. Hickson, Ying Liu
    Pages 471-482
  25. Oliver Quevedo, Michael Lisby
    Pages 483-493
  26. Anna H. Bizard, Christian F. Nielsen, Ian D. Hickson
    Pages 495-508
  27. Gregor W. Schmidt, Olivier Frey, Fabian Rudolf
    Pages 537-555
  28. Alice Meroni, Federico Lazzaro, Marco Muzi-Falconi, Alessandro Podestà
    Pages 557-573
  29. Eva-Maria Holstein, Conor Lawless, Peter Banks, David Lydall
    Pages 575-597
  30. Guðjón Ólafsson, Peter H. Thorpe
    Pages 599-612
  31. Ryuichiro Nakato, Katsuhiko Shirahige
    Pages 631-643
  32. Francisco M. Bastos de Oliveira, Dongsung Kim, Michael Lanz, Marcus B. Smolka
    Pages 645-660
  33. Anna H. Bizard, Christian F. Nielsen, Ian D. Hickson
    Pages E1-E1
  34. Back Matter
    Pages 661-663

About this book


This volume presents forty-two methods and protocols to analyze diverse aspects of genome instability. Chapters detail mutagenesis and repair, methods to quantify and analyze the properties of DNA double-strand breaks, profile replication, replication proteins strand-specifically, genome instability, fluorescence microscopic techniques, and genomic and proteomic approaches. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and cutting-edge, Genome Instability: Methods and Protocols aims to provide a comprehensive resource for the discovery and analysis of the proteins and pathways that are critical for stable maintenance of the genome.


eukaryotes telomere maintenance yeast stem cell renewal cancer biology

Editors and affiliations

  • Marco Muzi-Falconi
    • 1
  • Grant W Brown
    • 2
  1. 1.Dipartimento di BioscienzeUniversità degli Studi di MilanoMilanoItaly
  2. 2.Donnelly Centre and Department of BiochemistryUniversity of TorontoTorontoCanada

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media LLC 2018
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-7305-7
  • Online ISBN 978-1-4939-7306-4
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site