Overview
- Includes cutting-edge methods and protocols
- Provides step-by-step detail essential for reproducible results
- Contains key notes and implementation advice from the experts
Part of the book series: Methods in Molecular Biology (MIMB, volume 1641)
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Table of contents(23 protocols)
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Screening Assays for Developmental Toxicity
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Safety Biomarkers
About this book
This second edition provides up-to-date chapters and new chapters focusing on the most recent advances in the field of drug safety evaluation. Divided into seven parts, chapters detail specific aspects related to the experimental design of preclinical studies conducted to support the safety of pediatric and combination drugs, necropsy and histopathology evaluation, mass spectrometry imaging, genetic toxicology protocols including the Pig-a mutation assay, safety pharmacology methods such as automatization of patch-clamp procedures, target safety assessment for investigative toxicology, screening assays for developmental toxicology, and methods to characterize novel translational safety biomarkers like microRNAs. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting to avoid known pitfalls.
Authoritative and practical, Drug Safety Evaluation: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field.
Editors and Affiliations
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Preclinical Safety, Sanofi, R&D, Vitry-sur-Seine, France
Jean-Charles Gautier
Bibliographic Information
Book Title: Drug Safety Evaluation
Book Subtitle: Methods and Protocols
Editors: Jean-Charles Gautier
Series Title: Methods in Molecular Biology
DOI: https://doi.org/10.1007/978-1-4939-7172-5
Publisher: Humana New York, NY
eBook Packages: Springer Protocols
Copyright Information: Springer Science+Business Media LLC 2017
Hardcover ISBN: 978-1-4939-7170-1Published: 27 July 2017
Softcover ISBN: 978-1-4939-8406-0Published: 08 August 2018
eBook ISBN: 978-1-4939-7172-5Published: 25 July 2017
Series ISSN: 1064-3745
Series E-ISSN: 1940-6029
Edition Number: 2
Number of Pages: XI, 427
Number of Illustrations: 30 b/w illustrations, 28 illustrations in colour
Topics: Pharmacology/Toxicology