Book Volume 1488 2017

Systems Genetics

Methods and Protocols

Editors:

ISBN: 978-1-4939-6425-3 (Print) 978-1-4939-6427-7 (Online)

Table of contents (29 protocols)

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  1. Front Matter

    Pages i-xiv

  2. Resources for Systems Genetics

    1. Front Matter

      Pages 1-1

    2. No Access

      Protocol

      Pages 3-29

      Resources for Systems Genetics

    3. No Access

      Protocol

      Pages 31-44

      Heterogeneous Stock Populations for Analysis of Complex Traits

  3. Tools for Analysis and Integration in Systems Genetics

    1. Front Matter

      Pages 45-45

    2. No Access

      Protocol

      Pages 47-73

      Mouse Genome Informatics (MGI): Resources for Mining Mouse Genetic, Genomic, and Biological Data in Support of Primary and Translational Research

    3. No Access

      Protocol

      Pages 75-120

      GeneNetwork: A Toolbox for Systems Genetics

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      Protocol

      Pages 121-129

      Complex Trait Analyses of the Collaborative Cross: Tools and Databases

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      Protocol

      Pages 131-152

      Integrative Functional Genomics for Systems Genetics in GeneWeaver.org

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      Protocol

      Pages 153-188

      A Suite of Tools for Biologists That Improve Accessibility and Visualization of Large Systems Genetics Datasets: Applications to the Hybrid Mouse Diversity Panel

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      Protocol

      Pages 189-215

      Expression QTLs Mapping and Analysis: A Bayesian Perspective

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      Pages 217-237

      Epigenetics and Control of RNAs

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      Pages 239-250

      Integrating Multidimensional Data Sources to Identify Genes Regulating Complex Phenotypes

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      Protocol

      Pages 251-263

      RNA-Seq in the Collaborative Cross

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      Pages 265-281

      QTL Mapping and Identification of Candidate Genes in DO Mice: A Use Case Model Derived from a Benzene Toxicity Experiment

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      Protocol

      Pages 283-297

      Visualization of Results from Systems Genetics Studies in Chromosomal Context

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      Protocol

      Pages 299-317

      Using Baseline Transcriptional Connectomes in Rat to Identify Genetic Pathways Associated with Predisposition to Complex Traits

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      Protocol

      Pages 319-335

      Precise Network Modeling of Systems Genetics Data Using the Bayesian Network Webserver

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      Protocol

      Pages 337-362

      Systems Genetics as a Tool to Identify Master Genetic Regulators in Complex Disease

  4. Systems Genetics Use Cases: Mapping and Combining Multiple Phenotypic Traits

    1. Front Matter

      Pages 363-363

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      Protocol

      Pages 365-390

      Genomic Control of Retinal Cell Number: Challenges, Protocol, and Results

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      Protocol

      Pages 391-417

      Systems Genetics Analysis to Identify the Genetic Modulation of a Glaucoma-Associated Gene

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      Protocol

      Pages 419-430

      Genetic Dissection of Variation in Hippocampal Intra- and Infrapyramidal Mossy Fibers in the Mouse

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      Protocol

      Pages 431-454

      Complex Genetics of Cardiovascular Traits in Mice: F2-Mapping of QTLs and Their Underlying Genes

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