Mitochondria and Cell Death

  • David M.¬†Hockenbery

Part of the Cell Death in Biology and Diseases book series (CELLDEATH)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Liron Boyman, George S. B. Williams, W. Jonathan Lederer
    Pages 17-43
  3. Lorna Flanagan, Federico Lucantoni, J. H. M. Prehn
    Pages 45-67
  4. Frank Edlich, Jean-Claude Martinou
    Pages 69-83
  5. Guy A. Perkins, Mark H. Ellisman
    Pages 85-110
  6. Bryan G. Allen, Douglas R. Spitz
    Pages 111-130
  7. William J. Valente, Jason H. Bielas
    Pages 131-148
  8. Doris Germain
    Pages 149-167
  9. Nuno Raimundo, Lorena Fernandez-Mosquera, King Faisal Yambire
    Pages 169-186
  10. Sunil Thomas, Michael Gale Jr.
    Pages 187-212
  11. Andrew Oberst, Gabriel Ichim, Stephen W. G. Tait
    Pages 213-226
  12. Back Matter
    Pages 227-232

About this book


This volume examines the role of mitochondria in different types of cell death, including apoptotic and necrotic cell deaths. Topics discussed include mitochondrial outer membrane permeabilization (MOMP) and the permeability transition pore; core processes such as calcium handling, fission and fusion, reactive oxygen species generation, and maintenance of mitochondrial DNA fidelity and protein folding homeostasis; and retrograde signaling between mitochondria and other cellular components, including the important role of mitochondria in antiviral immunity. The expertly authored chapters are drawn from multidisciplinary international perspectives, lending a nuanced and comprehensive approach to the material.
Mitochondria and Cell Death, part of the Cell Death in Biology and Diseases series, is invaluable reading for graduate students, researchers, and clinicians in the fields of neuroscience, oncology, gastroenterology, and hepatology, as well as those interested in the study of mitochondria and cell biology.


Apoptosis intermembrane space interorganelle associations membrane permeability mitochondrial dynamics necroptosis sphingolipids

Editors and affiliations

  • David M.¬†Hockenbery
    • 1
  1. 1.Clinical Research DivisonFred Hutchinson Cancer Research CenterSeattleUSA

Bibliographic information