Effect of Spaceflight and Spaceflight Analogue Culture on Human and Microbial Cells

Novel Insights into Disease Mechanisms

  • Cheryl A. Nickerson
  • Neal R. Pellis
  • C. Mark Ott

Table of contents

  1. Front Matter
    Pages i-xviii
  2. The Principles and Translational Impact of Space Life Sciences Research

    1. Front Matter
      Pages 1-1
    2. Neal R. Pellis, Alexander Chouker, B. Yic, Svantje Tauber, Oliver Ullrich, A. Sundaresan
      Pages 3-37
    3. Buqing Yi, Brian Crucian, Svantje Tauber, Oliver Ullrich, Alexander Choukèr
      Pages 61-79
  3. Human Cellular Investigations

    1. Front Matter
      Pages 81-81
    2. Aurélie Crabbé, Jennifer Barrila, C. Mark Ott, Cheryl A. Nickerson
      Pages 93-119
    3. Ruoxiang Wang, Gina Chia-Yi Chu, Haiyen E. Zhau, Leland W. K. Chung
      Pages 131-150
  4. Microbial Investigations

    1. Front Matter
      Pages 197-197
    2. Duane L. Pierson, C. Mark Ott
      Pages 199-208
    3. Jennifer Barrila, James W. Wilson, Anjali Soni, Jiseon Yang, C. Mark Ott, Cheryl A. Nickerson
      Pages 209-235
    4. Sarah L. Castro, David W. Niesel, Jennifer Barrila, C. Mark Ott
      Pages 283-296
  5. Back Matter
    Pages 297-301

About this book


Many breakthroughs in biological research and translational healthcare advancements have been achieved by studying the response of biological systems to extreme environments. The spaceflight platform provides a unique environment where researchers can explore fundamental questions into cellular and molecular response mechanisms to unveil novel insight into human health and disease.  Since the physical force of gravity has shaped the architecture of all biological systems on our planet, spaceflight provides the opportunity to see life in a new adaptational mode - in response to reduced gravity. This enables investigations into the effects of the microgravity environment and associated changes in mechanical forces on mammalian cells/tissues and microbial pathogens, to bring novel insight into disease mechanisms, which are not discernable using conventional experimental approaches.

Research using spaceflight platforms represents a paradigm shift in how we observe life processes and is on the leading edge of research discoveries into cellular and molecular mechanisms of health and disease. By incorporating the views of leading authors, this book highlights landmark discoveries and advances in mammalian cellular and microbiology research in both true spaceflight and ground-based spaceflight analogue environments for scientists and students alike who are interested in the influence of physical forces on mammalian and microbial cells, how this impacts transition between normal homeostasis and disease, and basic mechanisms of adaptation to low gravity environments.  To provide a thorough understanding of this research, this book covers a range of topics including:

(i) description the physical forces interacting with cells in microgravity and microgravity analogue environments,

(ii) how alterations in these cellular forces impact human physiology, specifically immune function,

(iii) use of these environments to develop organotypic three-dimensional (3-D) tissue culture models as predictive human surrogates for organogenesis and disease research, and

(iv) microbial pathogen responses to culture in these environments, focusing on infectious disease 

Collectively, this information reflects a critical step in preparation for long-duration human space exploration, advances our knowledge of basic biological processes and mechanisms important to understand normal function and disease, and may lead to new strategies for treatment and prevention.


Infectious disease research Mechanotransduction Microbial Cells Microgravity Spaceflight Tissue engineering

Editors and affiliations

  • Cheryl A. Nickerson
    • 1
  • Neal R. Pellis
    • 2
  • C. Mark Ott
    • 3
  1. 1.School of Life Sciences The Biodesign Institute, Center for Infectious Diseases and VaccinologyArizona State UniversityTempeUSA
  2. 2.Division of Space Life ScienceUniversities Space Research AssociationHoustonUSA
  3. 3.Biomedical Research and Environmental Sciences DivisionNASA/Johnson Space CenterHoustonUSA

Bibliographic information