Designer Receptors Exclusively Activated by Designer Drugs

  • Gerald Thiel

Part of the Neuromethods book series (NM, volume 108)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Ken-ichiro Nakajima, Luis E. Diaz Gimenez, Vsevolod V. Gurevich, Jürgen Wess
    Pages 29-48
  3. Alexia Nunez-Parra, Krista Krahe, Wilson Chan, Ricardo C. Araneda
    Pages 83-94
  4. Charles D. Nichols, Jaime Becnel
    Pages 147-158
  5. Back Matter
    Pages 159-160

About this book


This volume provides current methods to analyze the properties of designer receptors exclusively activated by designer drugs (DREADDs) in vitro and to measure the biological responses of DREADD activation in different neuronal populations in vivo. Chapters focus on the utility of DREADD technology to selectively stimulate or inhibit neuronal activity in selected brain areas of transgenic mice. In addition, the successful use of DREADD expression in rats and Drosophila is described. Together, the DREADD technology represents a non-invasive, chemical-genetic tool for investigating neuronal signaling and the resulting behavioural responses in vivo. Written in the popular Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your own laboratory. Concise and easy-to-use, Designer Receptors Exclusively Activated by Designer Drugs aims to ensure successful results in the further study of this vital field.


CNO-stimulated designer receptors DREADD G protein G-protein coupled receptors GPCR signaling designer drug designer receptors hM3Dq heterologous G proteins transgenic mice

Editors and affiliations

  • Gerald Thiel
    • 1
  1. 1.Department of Medical Biochemistry and Molecular BiologyUniversity of Saarland Medical FacultyHomburgGermany

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2015
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-2943-6
  • Online ISBN 978-1-4939-2944-3
  • Series Print ISSN 0893-2336
  • Series Online ISSN 1940-6045
  • Buy this book on publisher's site