The Th2 Type Immune Response in Health and Disease

From Host Defense and Allergy to Metabolic Homeostasis and Beyond

  • William C. Gause
  • David Artis

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Bart N. Lambrecht, Mary van Helden, Hamida Hammad
    Pages 33-51
  3. Alex Loukas, Paul Giacomin
    Pages 97-114
  4. Alexander J. Chan, Jessica C. Jang, Meera G. Nair
    Pages 115-130
  5. Rowann Bowcutt, Martin J. Wolff, P’ng Loke
    Pages 131-154
  6. Priya Prahalad, Justin I. Odegaard, Ajay Chawla
    Pages 155-169
  7. Back Matter
    Pages 171-172

About this book


The type 2 immune response that develops during infectious disease has undergone major paradigm shifts in the last several years as new cell types and pathways have been identified.  It is now clear that the type 2 immune response, characterized by elevations in specific cytokines, including IL-4, IL-5 and IL-13, is associated with helminth infections in both humans and mice.  This response is complex and includes effector functions that mediate resistance, contributing to expulsion, and in some cases destruction, of the parasite.  But just as importantly, the type 2 immune response can also mediate tolerance mechanisms, which can mitigate tissue injury as these large multicellular parasites transit through vital organs.  The tolerance mechanisms include both tissue repair and immune regulatory effects. These latter aspects of the helminth-induced type 2 immune response are increasingly recognized as a potential resource that can be mined for the development of novel immunotherapies that may enhance wound healing, control of autoimmune and inflammatory diseases and regulation of metabolic homeostasis.  In this book, leading researchers in this exciting and dynamic field discuss the latest findings and emerging concepts, providing an intellectual framework that can be used as a basis for new discoveries and potentially new treatments for diseases associated with inflammation.


Helminth Immune response Parasites Th2 type immune response inflammation

Editors and affiliations

  • William C. Gause
    • 1
  • David Artis
    • 2
  1. 1.Rutgers, The State University of New Jer NEWARKUSA
  2. 2.Department of Microbiology and Immunology Belfer Research BuildingMichael Kors Professor of Immunology; Director, Jill Roberts Institute for Research in Inflammatory Bowel Disease; Weill Cornell Medical College; Cornell University; Joan and Sanford I. Weill Department of MedicineNew YorkUSA

Bibliographic information