Endothelial Signaling in Development and Disease

  • Mirko HH Schmidt
  • Stefan Liebner

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Development and Differentiation of the Vascular System

    1. Front Matter
      Pages 1-1
    2. Marcin Teodorczyk, Nevenka Dudvarski Stanković, Frank Bicker, Mirko HH Schmidt
      Pages 3-46
    3. Dorien M. A. Hermkens, Henricus J. Duckers, Stefan Schulte-Merker
      Pages 47-64
    4. Richard Daneman, Annika Keller
      Pages 65-92
    5. Igor Kovacevic, Meike Hoffmeister, Stefanie Oess
      Pages 93-114
    6. Jeremiah Bernier-Latmani, Amélie Sabine, Tatiana V. Petrova
      Pages 115-133
  3. Homeostasis of the Vascular System

    1. Front Matter
      Pages 135-135
    2. Luca Bravi, Maria Grazia Lampugnani
      Pages 137-160
    3. Mia Phillipson, Gustaf Christoffersson, Lena Claesson-Welsh, Michael Welsh
      Pages 187-207
    4. Christoph Reinhardt, Davit Manukyan, Wolfram Ruf
      Pages 233-256
  4. Pathophysiology of the Vascular System

    1. Front Matter
      Pages 257-257
    2. Robert Luck, Carmen Ruiz de Almodovar
      Pages 259-291
    3. Hans-Peter Hammes
      Pages 293-311
    4. Anne-Theres Henze, Massimiliano Mazzone
      Pages 329-349
    5. Michael Seimetz, Norbert Weissmann
      Pages 351-379
    6. Huige Li, Ning Xia, Ulrich Förstermann
      Pages 381-397
  5. Back Matter
    Pages 399-401

About this book


This book surveys healthy and diseased vascular systems in a multitude of model organisms and systems. It explores a plethora of functions, characteristics, and pathologies of the vascular system such as angiogenesis, fibroblast growth factor signaling, lymphangiogenesis, junctional signaling, the extracellular matrix, vascular permeability, leukocyte extravasation, axon guidance factors, the angiopoietin system, and chronic obstructive lung disease. Following a preface from leading researcher Dr. Holger Gerhardt, the text is divided into three sections- the first examining the development of the vascular system in a variety of contexts, the second delving into its homeostatic characteristics, and the third discussing its pathophysiologies.  The sixteen chapters, which represent international clinical and research perspectives, highlight the importance of molecular and signaling pathways for translational basic science and clinical medicine. Additionally, the text explores new and exciting fields in vascular biology research.


Comprehensive in both content and approach, Vascular Signaling in Health and Disease is ideal for graduate students, researchers, and clinicians interested in vascular biology, pneumology, and molecular biology.


Angiogenesis VEGF endothelial hypoxia signaling vascular

Editors and affiliations

  • Mirko HH Schmidt
    • 1
  • Stefan Liebner
    • 2
  1. 1.Microscopic Anatomy and Neurobiology Building 708, 2.Floor, R2.006Johannes Gutenberg University School of MedicineMainzGermany
  2. 2.Institute of Neurology Building 89, 4.Floor, R402Goethe University Frankfurt School of MedicineFrankfurtGermany

Bibliographic information