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Muscarinic Receptor: From Structure to Animal Models

  • Jaromir Myslivecek
  • Jan Jakubik

Part of the Neuromethods book series (NM, volume 107)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Ryoji Suno, Hidetsugu Asada, Takuya Kobayashi
    Pages 1-13
  3. Trayder Thomas, David K. Chalmers, Elizabeth Yuriev
    Pages 15-35
  4. Esam E. El-Fakahany, Jan Jakubik
    Pages 37-68
  5. Ikunobu Muramatsu, Hatsumi Yoshiki, Kiyonao Sada, Junsuke Uwada, Takanobu Taniguchi, Takayoshi Masuoka et al.
    Pages 69-81
  6. Wisuit Pradidarcheep, Martin C. Michel
    Pages 83-94
  7. Jan Jakubik, Esam E. El-Fakahany
    Pages 95-130
  8. Cornelius Krasel, Andreas Rinne, Moritz Bünemann
    Pages 147-158
  9. Hideo Tsukada, Shingo Nishiyama, Kazuhiro Takahashi
    Pages 181-203
  10. Ignaz Karl Wessler, Charles James Kirkpatrick
    Pages 205-220
  11. Takio Kitazawa, Hiroki Teraoka, Nao Harada, Kenta Ochi, Tatsuro Nakamura, Koichi Asakawa et al.
    Pages 235-259
  12. Back Matter
    Pages 283-287

About this book

Introduction

This volume provides methods for characterization of muscarinic receptor in crystallography studies that advanced our understanding of structural properties and activation mechanism of muscarinic receptors and are cornerstone in molecular modeling and computer‑based approaches to study muscarinic receptors. Muscarinic Receptor: From Structure to Animal Models guides readers through binding techniques, protocols to investigate molecular properties of muscarinic receptors, protocols to study muscarinic receptors in the central nervous system using autoradiography and PET studies, and protocols on animals with knock-out and knock-in muscarinic genes to study role of muscarinic receptors in physiology and behavior. Written in the popular Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your own laboratory.

 Concise and easy-to-use, Muscarinic Receptor: From Structure to Animal Models aims to ensure successful results in the further study of this vital field.

Keywords

PET studies autoradiography central nervous system crystallography heterologous expression systems knock-out& knock-in muscarinic genes ligands molecular modeling subtype selective ligands systemic level

Editors and affiliations

  • Jaromir Myslivecek
    • 1
  • Jan Jakubik
    • 2
  1. 1.Institute of PhysiologyCharles UniversityPragueCzech Republic
  2. 2.Department of NeurochemistryAcad. of Sciences of the Czech Rep. Institute of PhysiologyPragueCzech Republic

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4939-2858-3
  • Copyright Information Springer Science+Business Media New York 2016
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-2857-6
  • Online ISBN 978-1-4939-2858-3
  • Series Print ISSN 0893-2336
  • Series Online ISSN 1940-6045
  • Buy this book on publisher's site