Clinical Epidemiology

Practice and Methods

  • Patrick S. Parfrey
  • Brendan J. Barrett

Part of the Methods in Molecular Biology book series (MIMB, volume 1281)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. John D. Harnett, Richard Neuman
      Pages 19-30
    3. Geoffrey Warden
      Pages 31-48
  3. Longitudinal Studies

    1. Front Matter
      Pages 49-49
    2. Pietro Ravani, Brendan J. Barrett, Patrick S. Parfrey
      Pages 71-92
    3. Pietro Ravani, Brendan J. Barrett, Patrick S. Parfrey
      Pages 93-131
  4. Randomized Controlled Clinical Trials

    1. Front Matter
      Pages 157-157
    2. Bryan M. Curtis, Brendan J. Barrett, Patrick S. Parfrey
      Pages 159-175
    3. Robert N. Foley
      Pages 177-190
    4. Michelle M. Richardson, Megan E. Grobert, Klemens B. Meyer
      Pages 191-206
    5. Claudio Rigatto, Brendan J. Barrett
      Pages 207-224
    6. Elizabeth Hatfield, Elizabeth Dicks, Patrick S. Parfrey
      Pages 273-286
  5. The Basics for Other Clinical Epidemiology Methods

    1. Front Matter
      Pages 287-287
    2. John M. Fardy, Brendan J. Barrett
      Pages 289-300
    3. Deborah M. Gregory, Christine Y. Way
      Pages 301-313
    4. Braden J. Manns
      Pages 315-330
  6. Clinical Genetic Research

    1. Front Matter
      Pages 331-331
    2. Susan Stuckless, Patrick S. Parfrey
      Pages 333-348
    3. Darren D. O’Rielly, Proton Rahman
      Pages 349-367
  7. Methods in Evidence-Based Decision Making

    1. Front Matter
      Pages 383-383
    2. Aminu Bello, Natasha Wiebe, Amit Garg, Marcello Tonelli
      Pages 397-416
    3. Daria O’Reilly, Kaitryn Campbell, Meredith Vanstone, James M. Bowen, Lisa Schwartz, Nazila Assasi et al.
      Pages 417-441
    4. Deborah M. Gregory, Laurie K. Twells
      Pages 455-468
  8. Back Matter
    Pages 519-533

About this book


Focusing on improving the diagnosis, prognosis, and management of human disease, this book takes on the issues of research design, measurement, and evaluation which are critical to clinical epidemiology. This second edition of Clinical Epidemiology: Practice and Methods opens with how best to frame a clinical research question, the ethics associated with doing a research project in humans, and the definition of various biases that occur in clinical research. From there, it continues by examining issues of design, measurement, and analysis associated with various research designs, including determination of risk in longitudinal studies, assessment of therapy in randomized controlled clinical trials, and evaluation of diagnostic tests, and then delves into the more specialized area of clinical genetic research, before concluding with basic methods used in evidence-based decision making including critical appraisal, aggregation of multiple studies using meta-analysis, health technology assessment, clinical practice guidelines, development of health policy, translational research, how to utilize administrative databases, and knowledge translation. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and practical advice to ensure real world success.

Comprehensive and authoritative, Clinical Epidemiology: Practice and Methods, Second Edition is intended to educate researchers on how to undertake clinical research and should be helpful not only to medical practitioners but also to basic scientists who want to extend their work to humans, to allied health professionals interested in scientific evaluation, and to trainees in clinical epidemiology.


Clinical genetic research Clinical research Diagnosis and prognosis Evidence-based decision making Human disease management Longitudinal studies Randomized controlled trials Research design

Editors and affiliations

  • Patrick S. Parfrey
    • 1
  • Brendan J. Barrett
    • 2
  1. 1.Memorial University of NewfoundlandSt. John'sCanada
  2. 2.Memorial University of NewfoundlandSt. John'sCanada

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2015
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-2427-1
  • Online ISBN 978-1-4939-2428-8
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site