Gene Delivery and Therapy for Neurological Disorders

  • Xuenong Bo
  • Joost Verhaagen

Part of the Neuromethods book series (NM, volume 98)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Pádraig J. Mulcahy, Christopher Binny, Bartosz Muszynski, Evangelia Karyka, Mimoun Azzouz
    Pages 1-22
  3. Ioanna Eleftheriadou, Nicholas D. Mazarakis
    Pages 23-66
  4. Maya Woodbury, Tomomi Kiyota, Tsuneya Ikezu
    Pages 85-120
  5. Angela Wu, Dahna M. Fong, Deborah Young
    Pages 121-151
  6. Nitish D. Fagoe, Ruben Eggers, Joost Verhaagen, Matthew R. J. Mason
    Pages 175-189
  7. Fanxia Shen, Hua Su
    Pages 191-202
  8. Samantha R. de Silva, Michelle E. McClements, Mark W. Hankins, Robert E. MacLaren
    Pages 203-228
  9. En-Ju D. Lin, Matthew J. During
    Pages 229-264
  10. Diane Golebiowski, Allison M. Bradbury, Churl-Su Kwon, Imramsjah M. J. van der Bom, Lorelei Stoica, Aime K. Johnson et al.
    Pages 265-295
  11. John Lynes, Carl Koschmann, Mia Wibowo, Vandana Saxena, Marianela Candolfi, Mariela A. Moreno Ayala et al.
    Pages 341-354
  12. Back Matter
    Pages 355-359

About this book


This volume aims to explore the latest developments in adeno-associated viral and lentiviral vectors as well as the gene therapy strategies for the most common neurological disorders, followed by chapters that include step-by-step guides to viral vector-based gene delivery in animal models used in the authors’ laboratories. Although safe gene manipulation in neural cells can be achieved, it may still be years away from efficacious gene-based treatment of neurological disorders such as Parkinson's and Alzheimer’s diseases due to the complexity of the underlying genetic/molecular mechanisms and the difficulty of developing reliable animal models. Gene Delivery and Therapy for Neurological Disorders seeks to aid researchers in this vital work.  Written in the popular Neuromethods series format, chapters include the kind of detailed description and expert implementation advice that leads to success in the lab.

Meticulous and authoritative, Gene Delivery and Therapy for Neurological Disorders serves as an ideal guide for researchers attempting to explore the potentials of gene therapy for neurological disorders.


Adeno-associated viral vectors Animal models Gene expression manipulation Gene therapy Gene-based treatment Lentiviral vectors Neural cells Viral vector-based gene delivery

Editors and affiliations

  • Xuenong Bo
    • 1
  • Joost Verhaagen
    • 2
  1. 1.Queen Mary University of LondonLondonUnited Kingdom
  2. 2.Netherlands Institute for NeuroscienceAmsterdamThe Netherlands

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2015
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-2305-2
  • Online ISBN 978-1-4939-2306-9
  • Series Print ISSN 0893-2336
  • Series Online ISSN 1940-6045
  • Buy this book on publisher's site