Mouse Models of Cancer

Methods and Protocols

  • Robert Eferl
  • Emilio Casanova

Part of the Methods in Molecular Biology book series (MIMB, volume 1267)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Background

    1. Front Matter
      Pages 1-1
    2. Patricia Stiedl, Beatrice Grabner, Katalin Zboray, Edith Bogner, Emilio Casanova
      Pages 3-18
  3. Individual Cancers

    1. Front Matter
      Pages 45-45
    2. Kazuhito Sakamoto, Jeffrey W. Schmidt, Kay-Uwe Wagner
      Pages 47-71
    3. Elspeth A. Brzezinska, Colin Nixon, Rachana Patel, Hing Y. Leung
      Pages 73-91
    4. Roghaiyeh Safari, Ralph Meuwissen
      Pages 93-124
    5. Ilija Crncec, Paulina Pathria, Jasmin Svinka, Robert Eferl
      Pages 145-164
    6. Jorge Matias Caviglia, Robert F. Schwabe
      Pages 165-183
    7. Pawel K. Mazur, Alexander Herner, Florian Neff, Jens T. Siveke
      Pages 185-215
    8. Nicole Amberg, Martin Holcmann, Elisabeth Glitzner, Philipp Novoszel, Gabriel Stulnig, Maria Sibilia
      Pages 217-250
    9. Blake Ferguson, H. Peter Soyer, Graeme J. Walker
      Pages 251-261
    10. Christine Schneckenleithner, Andrea Hoelbl-Kovacic, Veronika Sexl
      Pages 263-282
    11. Rebecca D. Dodd, Leonor Añó, Jordan M. Blum, Zhizhong Li, David Van Mater, David G. Kirsch
      Pages 283-295
    12. Özge Uluçkan, Latifa Bakiri, Erwin F. Wagner
      Pages 297-305
  4. Specific Aspects

    1. Front Matter
      Pages 319-319
    2. Michael Bouvet, Robert M. Hoffman
      Pages 321-348
    3. Rumela Chakrabarti, Yibin Kang
      Pages 367-380
    4. Caroline Botta, Cedric Darini, Guillaume Darrasse-Jèze, Katrina Podsypanina
      Pages 381-394
    5. Sham S. Kakar, Cohin Kakar
      Pages 395-411
    6. Julia Specks, Maria Nieto-Soler, Andres J. Lopez-Contreras, Oscar Fernandez-Capetillo
      Pages 413-437
    7. Eva Bauer, Agnieszka Witalisz, Birgit Strobl, Dagmar Stoiber
      Pages 439-456
  5. Back Matter
    Pages 457-463

About this book


This volume is essential for geneticists, molecular biologists, biochemists, and medical doctors interested in the use of mouse models in cancer research. Recent genome studies, together with refined genetic engineering techniques, have greatly increased the value of using mice for research on cancer and other human disorders. The chapters of this book will support scientists in choosing the most suitable mouse models for their research questions. The book provides detailed methodological information for genetic or chemical induction of different types of cancer, histomorphometric cancer analysis, and in vivo imaging, as well as protocols to investigate oncogene addiction, immune surveillance, and hallmarks of cancer such as angiogenesis or metastasis. Four review-like articles provide background information on mouse technologies and histopathologic differences between mouse and human cancers. The mouse models described in individual chapters will fuel the understanding of cancer initiation, immune system roles, tumor angiogenesis, invasion, metastasis, and the relevance of molecular diversity observed among human cancers. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Cutting-edge and resourceful, Mouse Models of Cancers: Methods and Protocols, is a valuable laboratory resource for all researchers, from the graduate level upwards, who study cancer and new possibilities for its treatment.


cancer initiation cancer models cancer research genetics genome sequencing in vivo imaging metastatic tumor development mouse models primary tumor development

Editors and affiliations

  • Robert Eferl
    • 1
  • Emilio Casanova
    • 2
  1. 1.Medical University Vienna (MUV) Institute for Cancer ResearchViennaAustria
  2. 2.Research (LBI-CR)Medical University Vienna (MUV), Center of Physiology and Pharmacology & Ludwig Boltzmann Institute for CancerViennaAustria

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2015
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-2296-3
  • Online ISBN 978-1-4939-2297-0
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site