Tissue and Organ Regeneration in Adults

Extension of the Paradigm to Several Organs

  • Ioannis V.¬†Yannas

Table of contents

  1. Front Matter
    Pages i-xxii
  2. Ioannis V. Yannas
    Pages 1-25
  3. Ioannis V. Yannas
    Pages 27-46
  4. Ioannis V. Yannas
    Pages 63-87
  5. Ioannis V. Yannas
    Pages 89-136
  6. Ioannis V. Yannas
    Pages 137-178
  7. Ioannis V. Yannas
    Pages E1-E1
  8. Back Matter
    Pages 269-332

About this book


This textbook describes the basic principles of induced organ regeneration in skin and peripheral nerves and extends the original successful paradigm to other organs. A set of trans-organ rules is established and its use in regeneration of several organs is illustrated from the works of several independent investigators who worked with a variety of organs, such as the lung, the bladder, and the Achilles tendon, using collagen-based scaffolds somewhat similar to the original one. These critical medical treatments fill the clinical need that is not met by organ transplantation.

New to this second edition:

New information extending the paradigm of tissue regeneration from organ regeneration in skin and peripheral nerves to other organs

Guidelines, known as trans-organ rules, are described for the first time for extending this unique medical treatment to organs of several medical specialties

The work serves as a comprehensive text and reference for students and practitioners of tissue engineering



Alpha1beta1 integrin Alpha2beta1 integrin Assay for dermis Assay for scar Axon elongation Bladder Regeneration Blocking scar formation Collagen fiber orientation Collagen scaffold regeneration paradigm Collagen-binding integrins Contractile cell capsule Contractile cells Contraction blockade Critical axon elongation Integrin ligands Ligand density of scaffold surface Liver Regeneration Mechanism of Induced Regeneration Mechanism of scar formation Molecular biology of scaffold activity Myofibroblast orientation Myofibroblasts Neuroma Neuroma blocking Peripheral Nerve Regeneration Regeneration of Organs Regeneration paradigm Scaffold regeneration paradigm Scar formation Skin Regeneration Surface chemistry of scaffolds Tendon Regeneration Tissue Engineering Wound Healing Mechanism Wound contraction

Authors and affiliations

  • Ioannis V.¬†Yannas
    • 1
  1. 1.Mechanical and Biological EngineeringMassachusetts Institute of TechnologyCambridgeUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2015
  • Publisher Name Springer, New York, NY
  • eBook Packages Engineering
  • Print ISBN 978-1-4939-1864-5
  • Online ISBN 978-1-4939-1865-2
  • Buy this book on publisher's site