Humanized Mice for HIV Research

  • Larisa Y. Poluektova
  • J. Victor Garcia
  • Yoshio Koyanagi
  • Markus G. Manz
  • Andrew M. Tager

Table of contents

  1. Front Matter
    Pages i-xxi
  2. Mouse Genetic Background and Human Hematopoietic Stem Cells Biology

  3. Understanding of Human Immune Cells Development and Function in Mouse Environment

    1. Front Matter
      Pages 91-91
    2. Jean-Pierre Yves Scheerlinck
      Pages 93-108
    3. Nicolas Legrand, Hergen Spits
      Pages 109-125
    4. Hao Wei Li, Yong-Guang Yang, Megan Sykes
      Pages 127-140
    5. Julie Lang, Roberta Pelanda
      Pages 141-152
    6. Yan Li, Silvia Lopez-Lastra, Guillemette X. Masse, James P. Di Santo
      Pages 161-179
    7. Udo F. Hartwig, Maya C. André, Christian Münz
      Pages 181-192
    8. Maya Caroline André, Sonja Meixlsperger, Christian Münz
      Pages 193-205
  4. Humanized Mice for HIV-1 Virus Biology and Pathogenesis. Is It Possible to Address?

    1. Front Matter
      Pages 207-207
    2. Paul W. Denton, Morgan L. Chateau, J. Victor Garcia
      Pages 235-245
    3. Angela Wahl, J. Victor Garcia
      Pages 247-254
    4. Yoshio Koyanagi
      Pages 255-264
    5. Larisa Y. Poluektova, Adrian A. Epstein, Santhi Gorantla
      Pages 305-312
  5. Humanized Mice for HIV-1-Specific Adaptive Cellular and Humoral Immune Responses

    1. Front Matter
      Pages 313-313
    2. Brian Moldt, Dennis R. Burton
      Pages 315-324
    3. Edward Seung, Andrew M. Tager
      Pages 325-335
  6. Therapeutics Developments for HIV-1

    1. Front Matter
      Pages 337-337
    2. Nathalia G. Holt, Colin M. Exline, Orla Mulhern, Ursula Hofer, Kathleen A. Burke, Jill E. Oldenburg et al.
      Pages 407-416
    3. Scott G. Kitchen, Jerome A. Zack
      Pages 429-441
    4. Mireille Centlivre, Nicolas Legrand, Ben Berkhout
      Pages 443-454
  7. New Models for Other Human-Specific or Human Selective Pathogens

    1. Front Matter
      Pages 455-455
    2. Helene Strick-Marchand, Alexander Ploss
      Pages 457-467
    3. Anuja Mathew, Ramesh Akkina
      Pages 469-479
    4. Antoinette Labuschagné, Muazzam Jacobs
      Pages 481-492
    5. Shigeyoshi Fujiwara, Go Matsuda, Ken-Ichi Imadome
      Pages 493-508
    6. Madeleine Duc Dodon, Julien Villaudy, Louis Gazzolo, Gerold Feuer
      Pages 509-518
  8. New Horizons in Mouse Humanization

    1. Front Matter
      Pages 529-529
    2. J. Victor Garcia
      Pages 531-534

About this book


Over the last several years the field of humanized mice has matured and developed into an essential component of translational research for HIV/AIDS. Humanized mice serve both as vehicles for discovery and as highly sophisticated platforms for biomedical research. In addition, humanized mice have demonstrated outstanding potential for the investigation of critical aspects of the infection and pathogenesis of the hepatitis and herpes viruses, as well as highly relevant microbial infections such as tuberculosis and malaria.

Humanized Mice for HIV Research provides a comprehensive presentation of the history, evolution, applications, and current state of the art of this unique animal model.  As an expansion of twelve review articles that were published in Humanized Mice by Springer in 2008 (Eds: Nomura T, Watanabe T, Habu S), this book expertly captures the outstanding progress that has been made in the development, improvement, implementation, and validation of humanized mouse models. The first two parts of this book cover the basics of human-to-mouse xenotransplantation biology, and provide critical information about human immune cell development and function based on individual models created from different immunodeficient strains of mice. The third and fourth parts investigate HIV-1 biology, including different routes of transmission, prevention, treatment, pathogenesis, and the development of adaptive immunity in humanized mice. The fifth part shows the broad applicability of humanized mice for therapeutic development, from long-acting antiretroviral combinations to genetic manipulations with human cells and cell-based approaches. The sixth part includes liver tissue engineering and the expansion of humanized mice for many other human cell-tropic pathogens.  

About the Editors

The Editors have well-documented track records in each of the subject areas covered, including HIV neuropathogenesis and therapeutics (Larisa Y. Poluektova, University of Nebraska Medical Center, Omaha, USA), developing novel humanized mouse models and pioneering applications for HIV transmission, prevention, persistency and eradication (J. Victor Garcia, University of North Carolina at Chapel Hill, USA), retrovirology and host restriction factors (Yoshio Koyanagi, Center for Human Retrovirus Research, Institute for Virus Research, Kyoto University, Japan), hematopoiesis and cytokine transgenic expression (Markus G. Manz, Division of Hematology, University Hospital Zürich, Switzerland), and developing adaptive immunity to HIV in humanized mice (Andrew M. Tager, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Ragon Institute of MGH, MIT and Harvard, USA). 


HIV Immune system function Mouse-to-human xenotransplantation humanized mice

Editors and affiliations

  • Larisa Y. Poluektova
    • 1
  • J. Victor Garcia
    • 2
  • Yoshio Koyanagi
    • 3
  • Markus G. Manz
    • 4
  • Andrew M. Tager
    • 5
  1. 1.Department of Pharmacology and Experimental NeuroscienceUniversity of Nebraska Medical CenterOmahaUSA
  2. 2.Center for AIDS ResearchThe University of North Carolina at Chapel HillChapel HillUSA
  3. 3.Research Center for AIDS Laboratory of Viral PathogenesisKyoto University Institute for Virus ResearchSakyo-kuJapan
  4. 4.Division of HematologyUniversity Hospital ZürichZürichSwitzerland
  5. 5.Center for Immunology and Inflammatory DiseasesMassachusetts General Hospital, Harvard Medical SchoolCharlestownUSA

Bibliographic information