Osteoporosis and Osteoarthritis

  • Jennifer J. Westendorf
  • Andre J. van Wijnen

Part of the Methods in Molecular Biology book series (MIMB, volume 1226)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Cell Biology

    1. Front Matter
      Pages 1-1
    2. Amber Rath Stern, Lynda F. Bonewald
      Pages 3-10
    3. Jennifer H. Jonason, Donna Hoak, Regis J. O’Keefe
      Pages 11-18
    4. Ji Zhu, Valerie A. Siclari, Ling Qin
      Pages 19-29
  3. Molecular Biology

    1. Front Matter
      Pages 59-59
    2. Bram C. van der Eerden, Rodrigo D. Alves, Christel E. Kockx, Zeliha Ozgur, Marijke Schreuders-Koedam, Jeroen van de Peppel et al.
      Pages 71-85
    3. Crystal Idleburg, Elizabeth N. DeLassus, Deborah V. Novack
      Pages 87-95
  4. Biomechanics and Imaging

    1. Front Matter
      Pages 97-97
    2. Katherine M. Melville, Alexander G. Robling, Marjolein C. H. van der Meulen
      Pages 99-115
    3. Angela S. P. Lin, Giuliana E. Salazar-Noratto, Robert E. Guldberg
      Pages 131-140
  5. In Vivo Models of Disease and Repair

    1. Front Matter
      Pages 141-141
    2. Kirsty L. Culley, Cecilia L. Dragomir, Jun Chang, Elisabeth B. Wondimu, Jonathan Coico, Darren A. Plumb et al.
      Pages 143-173
    3. Margaret J. Piel, Jeffrey S. Kroin, Hee-Jeong Im
      Pages 175-181
  6. Back Matter
    Pages 213-214

About this book


In Osteoporosis and Osteoarthritis expert investigators detail modern tools to enhance discovery in bone and cartilage biology and promote translational research in osteoporosis and osteoarthritis. New chapters describe methods to generate induced pluripotent stem cells, perform high-throughput chromatin analysis, assess loads on bone cells in vivo and in vitro, use state-of-the art imaging techniques to measure articular cartilage thickness and biochemical properties, and establish animal models of osteoarthritis and bone healing. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, Osteoporosis and Osteoarthritis shares successful techniques that can be applied to the study of either disease.


articular cartilage thickness bone cells bone healing chondrocytes chromatin analysis disease detection mesenchymal progenitor cells microRNAs in human plasma osteoarthritis disease progression osteoblasts osteocytes pluripotent stem cells skeletal tissues

Editors and affiliations

  • Jennifer J. Westendorf
    • 1
  • Andre J. van Wijnen
    • 2
  1. 1.Mayo ClinicRochesterUSA
  2. 2.Mayo ClinicRochesterUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2015
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-1618-4
  • Online ISBN 978-1-4939-1619-1
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site